Results 101 to 110 of about 2,584,400 (274)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

When are adjectives raisers? Tough to get it

Bucharest Working Papers in Linguistics, 2007
This article deals with some unsolved problems raised by tough-adjectives in Romance languages. We present some new data from some Romance languages (Romanian, French, Italian) supporting a raising analysis, and we argue that in these languages, unlike ...
Ion Giurgea, Elena Soare
doaj  

Content and Dietary Contribution Assessment of Mineral Elements in Dairy from Henan Province of China

Foods
To fill the gap in systematic data on mineral contents and their dietary contributions in four mainstream dairy products (sterilized, pasteurized, fermented, modified milk) from Henan Province, China, this study aimed to characterize the mineral profiles
Chuanyou Su, Han Li, Yi Li, Chunyu Feng, Tong Fu, Tianliu Zhang, Tengyun Gao   +6 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

To what extent does Together with Gloria! expand the reach of SASA! Together community programming? A mixed methods evaluation of an edutainment intervention in Kasese, Uganda

BMC Public Health
Background Community-level interventions to prevent violence against women (VAW), though potentially efficacious, are challenging to implement at scale, requiring intensive long-term engagement.
Tanya Abramsky, Shaffa Hameed, Junior Brian Musenze, Alice Witt, Herbert Mugooda, Dan Opito, Esther Awino, Gabriella Pinto, Sophie Namy, Janet Nakuti, Ana Maria Buller   +10 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Microbiomic and Metabolomic Insights into the Mechanisms of Alfalfa Polysaccharides and Seaweed Polysaccharides in Alleviating Diarrhea in Pre-Weaning Holstein Calves

Animals
Neonatal calves’ diarrhea, which can be severe enough to cause death, has a significant impact on the global cattle industry. In this study, alfalfa polysaccharides and seaweed polysaccharides were found to significantly improve the diarrhea condition in
Jianan Zhao, Haoliang Tian, Xiaohui Kong, Danqi Dang, Kaizhen Liu, Chuanyou Su, Hongxia Lian, Tengyun Gao, Tong Fu, Liyang Zhang, Wenqing Li, Wei Zhang   +11 more
doaj   +1 more source

Raising the Minimum Wage: Key Facts and Figures [PDF]

, 2014
In New York State, roughly 37% or workers earn low wages (less than $15 per hour, or $31,200 per year). In Erie County, the percentage is 41% (159,800 of 393,600 wage-earning workers). 94% of low wage workers in New York State are age 20 or over.
Partnership for the Public Good
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source