Results 61 to 70 of about 2,584,400 (274)
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Raising Our Game: Can We Sustain Globalization? [PDF]
, 2007 Depicts four alternate scenarios of the state of sustainable development and globalization in the year 2027, and looks at the associated environmental and societal wins and losses of each ...
Ivana Gazibara +7 more
core
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Glossa, 2020 The paper presents and examines a previously undescribed puzzle concerning the syntactic distribution of Russian mandative verbs (velet’ ‘order’, razrešit’ ‘allow’) and non-verbal deontic modals: these predicates exhibit dual behavior as they embed non ...
Irina Burukina
doaj +2 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Romanian restrictive relatives: A head raising analysis?
Bucharest Working Papers in Linguistics, 2010 The paper investigates the syntax of restrictive relative clauses from a mainly descriptive viewpoint. It offers a critical view of the head raising analysis (Kayne 1994) and shows that no conclusive evidence supports the application of this analysis to ...
Anca Sevcenco
doaj
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Restructuring strategies as means of providing increased referentiality for the internal argument of the de-supine clause [PDF]
Bucharest Working Papers in Linguistics, 2011 We analyse supines introduced by the complementizer de, regarding the syntax and interpretation of the internal argument (= IA). Syntactically, we focus on how the IA values its case feature.
Alexandra Cornilescu, Ruxandra Cosma
doaj
Freedom in the Dutch middle-field: Deriving discourse structure at the syntax-pragmatics interface
Glossa, 2020 This paper experimentally explores the optionality of Dutch scrambling structures with a definite object and an adverb. Most researchers argue that such structures are not freely interchangeable, but are subject to a strict discourse template.
Gert-Jan Thomas Schoenmakers
doaj +2 more sources
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source