Results 71 to 80 of about 2,584,400 (274)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Associations between violence in childhood, depression and suicide attempts in adolescence: evidence from a cohort study in Luwero district, Uganda

open access: yesBMC Public Health
Background Many studies have documented an association between violence victimisation and poor mental health. However, few studies use longitudinal data from low- and middle-income countries with attention to how associations differ by experiencing ...
Rebecca Akunzirwe   +14 more
doaj   +1 more source

On the CUSP: the politics and prospects of scaling social norms change programming

open access: yesSexual and Reproductive Health Matters, 2019
In the past decades, donors and development actors have been increasingly mindful of the evidence to support long-term, dynamic social norms change. This paper draws lessons and implications on scaling social norms change initiatives for gender equality ...
Leah Goldmann   +6 more
doaj   +1 more source

Profit Raising Entry [PDF]

open access: yes
Common wisdom suggests that entry reduces profits of the incumbent firms. On the contrary, we show that if the incumbents differ in marginal costs and the entrants behave like Stackelberg followers, entry may benefit the incumbents who are relatively ...
Arijit Mukherjee, Laixun Zhao
core  

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Mega-Events and Housing Costs: Raising the Rent while Raising the Roof? [PDF]

open access: yes
This paper examines the relationship between hosting mega-events such as the Super Bowl, Olympics, and World Cup and rental housing prices in host cities.
Dennis Coates, Victor Matheson
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

On the level raising of cuspidal eigenforms modulo prime powers [PDF]

open access: yes, 2018
In this article we prove level raising for cuspidal eigenforms modulo prime powers (for odd primes) of weight $k\geq 2$ and arbitrary character, extending the result in weight two established by the work of Tsaknias and Wiese and generalizing (partially)
Torti, Emiliano
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

WWW.raising achievement: internet research resources on raising achievement in post-compulsory education; the agency comments [PDF]

open access: yes, 2001
This report is designed to help practitioners and researchers find and use internet-based resources that deal with raising achievement. It contains a guide to useful research sources and organisations accessible via the internet; an introductory ...
Sawbridge, Stephen J
core  

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