Results 71 to 80 of about 481,812 (83)
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Organic Process Research & Development, 2012
Multiple sources of anticipated degradation and process impurities of raltegravir potassium drug substance observed during the laboratory optimization and later during its bulk synthesis are described in this article. The impurities were monitored by UPLC, and their structures are tentatively assigned on the basis of fragmentation patterns in LC–MS and
Golak C. Maikap +8 more
openaire +3 more sources
Multiple sources of anticipated degradation and process impurities of raltegravir potassium drug substance observed during the laboratory optimization and later during its bulk synthesis are described in this article. The impurities were monitored by UPLC, and their structures are tentatively assigned on the basis of fragmentation patterns in LC–MS and
Golak C. Maikap +8 more
openaire +3 more sources
Organic Process Research & Development, 2010
A manufacturing route for the synthesis of raltegravir potassium 1 was developed via a thermal rearrangement of amidoxime DMAD adducts 6 to construct the key, highly functionalized hydroxypyrimidin...
David Askin +10 more
openaire +3 more sources
A manufacturing route for the synthesis of raltegravir potassium 1 was developed via a thermal rearrangement of amidoxime DMAD adducts 6 to construct the key, highly functionalized hydroxypyrimidin...
David Askin +10 more
openaire +3 more sources
HIV‐1 integrase inhibitor raltegravir promotes DNA damage‐induced apoptosis in multiple myeloma
Chemical Biology and Drug Design, 2023Raltegravir, the first integrase inhibitor approved for the treatment of HIV infection, has been implicated as a promising potential in cancer treatment.
Dilara Akcora-Yildiz +4 more
semanticscholar +1 more source
Hepatic steatosis associated with exposure to elvitegravir and raltegravir.
Clinical Infectious Diseases, 2021Moderate-to-severe hepatic steatosis in people living with HIV without viral hepatitis or excessive alcohol intake was associated with cumulative exposure to stavudine, elvitegravir and raltegravir.
D. Kirkegaard-Klitbo +5 more
semanticscholar +1 more source
Clinical Infectious Diseases, 2020
BACKGROUND Although some integrase strand transfer inhibitors (INSTIs) promote peripheral and central adipose tissue/weight gain in HIV-infected individuals, the underlying mechanism has not been identified.
Jennifer Gorwood +16 more
semanticscholar +1 more source
BACKGROUND Although some integrase strand transfer inhibitors (INSTIs) promote peripheral and central adipose tissue/weight gain in HIV-infected individuals, the underlying mechanism has not been identified.
Jennifer Gorwood +16 more
semanticscholar +1 more source
Advancements and Challenges in Potassium Ion Batteries: A Comprehensive Review
Advanced Functional Materials, 2020Demand for energy in day to day life is increasing exponentially. However, existing energy storage technologies like lithium ion batteries cannot stand alone to fulfill future needs.
Ranjusha Rajagopalan +4 more
semanticscholar +1 more source
Advanced Carbon‐Based Anodes for Potassium‐Ion Batteries
Advanced Energy Materials, 2019The ever‐increasing demand for large‐scale energy storage systems requires novel battery technologies with low‐cost and sustainable properties. Due to earth‐abundance and cost effectiveness, the development of rechargeable potassium ion batteries (PIBs ...
Xuan Wu +6 more
semanticscholar +1 more source
Role of Potassium in Plant Photosynthesis, Transport, Growth and Yield
Role of Potassium in Abiotic Stress, 2022Jyoti Rawat, N. Pandey, J. Saxena
semanticscholar +1 more source