Results 171 to 180 of about 1,535,509 (313)

Bayesian linear mixed model with multiple random effects for prediction analysis on high-dimensional multi-omics data. [PDF]

Bioinformatics, 2023
Hai Y, Ma J, Yang K, Wen Y.
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Efficacy and Tolerability Outcomes of Minimally Invasive Surgical Treatments for Benign Prostatic Hyperplasia: A Random-Effects Network Meta-Analysis. [PDF]

World J Mens Health
Shin BNH, Maksoud R, Tan S, Rhee H, Park HJ, Chung E.   +5 more
europepmc   +1 more source

Goodness-of-fit tests in proportional hazards models with random effects. [PDF]

Biom J, 2023
González-Manteiga W, Martínez-Miranda MD, Van Keilegom I.   +2 more
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

A convexity-constrained parameterization of the random effects generalized partial credit model. [PDF]

Br J Math Stat Psychol
Hessen DJ.
europepmc   +1 more source

Operational characteristics of full random effects modelling ('frem') compared to stepwise covariate modelling ('scm'). [PDF]

J Pharmacokinet Pharmacodyn, 2023
Amann LF, Wicha SG.
europepmc   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Exact Inference for Random Effects Meta-Analyses for Small, Sparse Data. [PDF]

Stats (Basel)
Gronsbell J, McCaw ZR, Regis T, Tian L.
europepmc   +1 more source

An introduction to the full random effects model. [PDF]

CPT Pharmacometrics Syst Pharmacol, 2022
Yngman G, Bjugård Nyberg H, Nyberg J, Jonsson EN, Karlsson MO.   +4 more
europepmc   +1 more source