Results 71 to 80 of about 4,430,595 (297)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Accurately Estimating Correlations Between Demographic Parameters: A Response to Riecke Et al. (2024)

Ecology and Evolution
Correlations between annual recovery and survival probabilities estimated from tag‐recovery data have been used to quantify the demographic response of exploited populations to harvest. Deane et al.
Cody E. Deane, Lindsay G. Carlson, Curry J. Cunningham, Pat Doak, Knut Kielland, Greg A. Breed   +5 more
doaj   +1 more source

Linear Mixed Models: Gum and Beyond

Measurement Science Review, 2014
In Annex H.5, the Guide to the Evaluation of Uncertainty in Measurement (GUM) [1] recognizes the necessity to analyze certain types of experiments by applying random effects ANOVA models.
Arendacká Barbora, Täubner Angelika, Eichstädt Sascha, Bruns Thomas, Elster Clemens   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Parametrizations, fixed and random effects

Journal of Multivariate Analysis, 2017
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Dermoune, Azzouz, Preda, Cristian
openaire   +4 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Zero-inflated and distributed lag nonlinear models with random effects for assessing environmental impacts on respiratory health in peripheral regions of Costa Rica

Frontiers in Public Health
IntroductionClimate change and air pollution are key determinants of public health, particularly in the onset and exacerbation of respiratory diseases.
Shu Wei Chou-Chen, Emanuelle Parra-Rodríguez, Emanuelle Parra-Rodríguez   +2 more
doaj   +1 more source

The R Package JMbayes for Fitting Joint Models for Longitudinal and Time-to-Event Data Using MCMC

Journal of Statistical Software, 2016
Joint models for longitudinal and time-to-event data constitute an attractive modeling framework that has received a lot of interest in the recent years.
Dimitris Rizopoulos
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Empirical Bayes for group (DCM) studies: a reproducibility study

Frontiers in Human Neuroscience, 2015
This technical note addresses some key reproducibility issues in the dynamic causal modelling of group studies of event related potentials. Specifically, we address the reproducibility of Bayesian model comparison (and inferences about model parameters ...
Vladimir eLitvak, Marta eGarrido, Peter eZeidman, Karl eFriston   +3 more
doaj   +1 more source