Results 51 to 60 of about 3,684,995 (295)

Fixed and Random Effects Selection in Mixed Effects Models [PDF]

Biometrics, 2010
We consider selecting both fixed and random effects in a general class of mixed effects models using maximum penalized likelihood (MPL) estimation along with the smoothly clipped absolute deviation (SCAD) and adaptive LASSO (ALASSO) penalty functions. The maximum penalized likelihood estimates are shown to posses consistency and sparsity properties and
Ibrahim, Joseph G., Zhu, Hongtu, Garcia, Ramon I., Guo, Ruixin   +3 more
openaire   +3 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Results of international standardised beekeeper surveys of colony losses for winter 2012-2013 : analysis of winter loss rates and mixed effects modelling of risk factors for winter loss. [PDF]

, 2014
This article presents results of an analysis of winter losses of honey bee colonies from 19 mainly European countries, most of which implemented the standardised 2013 COLOSS questionnaire.
Aivar Raudmets, Alison Gray, Ari Seppälä, BATES D, Bjørn Dahle, BORNMANN L, Christoph Otten, Flemming Vejsnæs, Franco Mutinelli, GRAY A, Grażyna Topolska, Jean-Daniel Charrière, Justinas Kretavicius, Lassi Kauko, Magnus Peterson, Marica M Drazic, Mary F Coffey, MUTINELLI F, Preben Kristiansen, R DEVELOPMENT CORE TEAM, Robert Brodschneider, Romée van der Zee, Róbert Chlebo, Valters Brusbardis, VAN DER ZEE R, VANENGELSDORP D, Victoria Soroker, Violeta Santrac   +27 more
core   +1 more source

Bayesian exponential random graph models with nodal random effects [PDF]

Social Networks, 2016
We extend the well-known and widely used Exponential Random Graph Model (ERGM) by including nodal random effects to compensate for heterogeneity in the nodes of a network. The Bayesian framework for ERGMs proposed by Caimo and Friel (2011) yields the basis of our modelling algorithm.
Stephanie Thiemichen, Nial Friel, Alberto Caimo, Göran Kauermann   +3 more
openaire   +6 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Investigating the Relationship between Health Expenditures and Human Development Index: A Cross Country Analysis

Rāhburdhā-yi Mudīriyyat dar Niẓām-i Salāmat, 2022
Background: In recent decades, the human development index has become one of the most practical indicators for measuring the level of development in countries.
Zakiyeh Rahimi, Roohollah Babaki, Mahnaz Efati   +2 more
doaj  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Leveraging Fecal Bacterial Survey Data to Predict Colorectal Tumors

Frontiers in Genetics, 2019
Colorectal cancer (CRC) ranks second in cancer-associated mortality and third in the incidence worldwide. Most of CRC follow adenoma-carcinoma sequence, and have more than 90% chance of survival if diagnosed at early stage.
Bangzhou Zhang, Bangzhou Zhang, Shuangbin Xu, Wei Xu, Qiongyun Chen, Qiongyun Chen, Zhangran Chen, Changsheng Yan, Yanyun Fan, Huangkai Zhang, Qi Liu, Jie Yang, Jinfeng Yang, Chuanxing Xiao, Chuanxing Xiao, Hongzhi Xu, Hongzhi Xu, Jianlin Ren, Jianlin Ren   +18 more
doaj   +1 more source

Damage spreading in random field systems

, 1997
We investigate how a quenched random field influences the damage spreading transition in kinetic Ising models. To this end we generalize a recent master equation approach and derive an effective field theory for damage spreading in random field systems ...
Campbell I A, Coniglio A, Costa U, Derrida B, Derrida B, Glotzer S C, Grassberger P, Hinrichsen H, Kauffman A, Le Caër G, Schuster H G, Tamarit F A, Thomas Vojta, Vojta T, Vojta T, Wang F, Wang F   +16 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source