Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape
Advanced Science, EarlyView.Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim +12 more
wiley +1 more source
Correction: Application of XGBoost and Random Forest algorithms for body weight prediction in Blackbelly sheep using biometric measurements. [PDF]
BMC Vet ResDelgado MÁG +14 more
europepmc +1 more source
Advanced Science, EarlyView.In an invasive beetle–fungus complex, the mutualist Leptographium procerum induces host HSP83 and modulates Toll‐dependent antifungal immunity. HSP83 mediates two‐tiered control by associating with selected fungal recognition receptors and restraining Dorsal‐driven antimicrobial peptide transcription.
Qingtai Yang +8 more
wiley +1 more source
Global Future Modeling of the Monophagous Pest <i>Pagiophloeus tsushimanus</i> (Coleoptera: Curculionidae): An Integrated Approach Using Random Forest and the CLIMEX Model. [PDF]
InsectsWu Q +6 more
europepmc +1 more source
Constrained Forest Methane Sink by Thermal Adaptation of Soil Methanotrophs
Advanced Science, EarlyView.Climate warming can stimulate methanotroph‐mediated CH4 oxidation in forest soils, thereby mitigating the increase in atmospheric CH4 concentrations. By integrating evidence from a macro‐climatic thermal gradient and a 70‐day incubation experiment, this study demonstrates that microbial methanotrophs can adapt to long‐term temperature changes at the ...
Baizhi Jiang +5 more
wiley +1 more source
Construction and verification of an early warning model for hypothermia in emergency trauma patients based on the random forest method. [PDF]
Am J Transl ResCao J, Mu X, Zhu H, Liu Y.
europepmc +1 more source
Robots and Minimal, Physics‐Informed Features: A Hybrid Framework for Enzyme Catalysis
Advanced Science, EarlyView.Robotic experimentation and physics‐informed machine learning combine to predict enzyme substrate scope. With a handful of interpretable features derived from docking and quantum mechanics calculations, our model rivals descriptor‐heavy AI approaches and extrapolates to unseen substrates and enzyme classes.
Natalia Onishchenko +8 more
wiley +1 more source
Predicting Pregnancy After Fixed-Time Artificial Insemination in Goats: Comparative Performance of Multivariable Logistic Regression and Random Forest Models. [PDF]
Animals (Basel)Rodríguez-Vargas A +6 more
europepmc +1 more source
Advanced Science, EarlyView.An in situ dual‐mode platform integrates fusogenic liposomes with localized autocatalytic DNA circuits for plasma‐derived extracellular vesicle microRNA analysis. Following membrane fusion, target miRNAs trigger feedback‐assisted LECHA amplification inside intact vesicles, generating fluorescence and electrochemical outputs. Machine learning integrates
Wenbin Li +15 more
wiley +1 more source