Results 261 to 270 of about 2,068,010 (305)

Using random forests to uncover the predictive power of distance-varying cell interactions in tumor microenvironments. [PDF]

PLoS Comput Biol
VanderDoes J, Marceaux C, Yokote K, Asselin-Labat ML, Rice G, Hywood JD.   +5 more
europepmc   +1 more source

Groundwater Rise Sustains the World's Largest Alpine Water System Under Global Warming

Advanced Science, EarlyView.
Shallow groundwater depth (SGWD) across the non‐permafrost plains of the Qinghai–Xizang Plateau decreased at averagely 0.02 m year−1, adding 31.44 Gt of freshwater storage from 2000 to 2020 and sustaining ∼53 500 km2 of alpine ecosystems. A vadose‐zone capacity of 426.6 Gt reveals these aquifers as promising reservoirs, highlighting groundwater's ...
Jianqing Du, Zhixiang Niu, Yanfen Wang, Shirui Zhou, Youqing Yang, Xiang Wei, Haishan Niu, Yitao Zhang, Anquan Xia, Yali Liu, Yanbin Hao, Kai Xue, Bingfang Wu, Xinquan Zhao, Tandong Yao, Yiyu Chen   +15 more
wiley   +1 more source

Random forests with parametric entropy-based information gains for classification and regression problems. [PDF]

PeerJ Comput Sci
Ignatenko V, Surkov A, Koltcov S.
europepmc   +1 more source

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

Nanoparticle‐Mediated TIPE1 mRNA Delivery Enhances Paclitaxel Sensitivity in Triple‐Negative Breast Cancer by Modulating RAB7A Ubiquitination‐Associated Stability and Autophagy

Advanced Science, EarlyView.
TIPE1m NPs nanoparticles restore TIPE1 expression, promote RAB7A ubiquitination and degradation, suppress autophagic flux, and resensitize paclitaxel‐resistant triple‐negative breast cancer to therapy. ABSTRACT Acquired paclitaxel (PTX) resistance remains a major obstacle in triple‐negative breast cancer (TNBC) treatment.
Wei Hu, Qishuai Chen, Yan Ma, Yang Liu, Xianing Dong, Wenjuan Wei, Jianxin Du, Shusheng Qiu, Maojin Tian, Peiqing Zhao   +9 more
wiley   +1 more source

AI-driven discovery of blood xenobiotic biomarkers in neovascular age-related macular degeneration using iterative random forests. [PDF]

Graefes Arch Clin Exp Ophthalmol
Künzel SE, Frentzel DP, Flesch LTM, Knecht VA, Rübsam A, Dreher F, Schütte M, Dubrac A, Lange B, Yaspo ML, Lehrach H, Joussen AM, Zeitz O.   +12 more
europepmc   +1 more source

TSTScope Unifies Single‐Cell Multi‐Omics to Identify Functional T Cell States Predictive of Immunotherapy Response

Advanced Science, EarlyView.
TSTScope is an interpretable AI framework that integrates single‐cell transcriptomes with TCR information through curated gene‐program constraints. By linking receptor context to functional T cell states, it reveals response‐associated tumor‐specific T cell programs in lung cancer immunotherapy cohorts and defines an MPR score associated with ...
Shiwei Cao, Jinyu Cheng, Feng‐ao Wang, Chenxin Yi, Jiajun Chen, Keyue Wang, Lulu Liu, Junwei Liu, Yixue Li   +8 more
wiley   +1 more source

Exploring the predictors affecting the sense of community of Korean high school students: application of random forests and SHAP. [PDF]

Front Psychol
Jang E, Chung H.
europepmc   +1 more source

Predicting nutrition and environmental factors associated with female reproductive disorders using a knowledge graph and random forests. [PDF]

Int J Med Inform
Chan LE, Casiraghi E, Reese J, Harmon QE, Schaper K, Hegde H, Valentini G, Schmitt C, Motsinger-Reif A, Hall JE, Mungall CJ, Robinson PN, Haendel MA.   +12 more
europepmc   +1 more source

Quantifying salinity in calcareous soils through advanced spectroscopic models: A comparative study of random forests and regression techniques across diverse land use systems. [PDF]

PLoS One
Tahmoures M, Honarbakhsh A, Afzali SF, Nourzadeh Hadad M, Ostovari Y.   +4 more
europepmc   +1 more source