Results 101 to 110 of about 801,980 (275)
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
On a Stochastic Regularization Technique for Ill-Conditioned Linear Systems
Open Engineering, 2019 Knowledge about the input–output relations of a system can be very important in many practical situations in engineering. Linear systems theory comes from applied mathematics as an efficient and simple modeling technique for input–output systems ...
Moura Henrique Gomes +3 more
doaj +1 more source
Chaos and random matrices in supersymmetric SYK
Journal of High Energy Physics, 2018 We use random matrix theory to explore late-time chaos in supersymmetric quantum mechanical systems. Motivated by the recent study of supersymmetric SYK models and their random matrix classification, we consider the Wishart-Laguerre unitary ensemble and ...
Nicholas Hunter-Jones, Junyu Liu
doaj +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
On the Gaussian Random Matrix Ensembles with Additional Symmetry Conditions
Symmetry, Integrability and Geometry: Methods and Applications, 2006 The Gaussian unitary random matrix ensembles satisfying some additional symmetry conditions are considered. The effect of these conditions on the limiting normalized counting measures and correlation functions is studied.
Vladimir Vasilchuk
doaj
On the Spectral Form Factor for Random Matrices. [PDF]
Commun Math Phys, 2023 Cipolloni G, Erdős L, Schröder D.
europepmc +1 more source
FEBS Open Bio, EarlyView.Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin +3 more
wiley +1 more source
Random matrices: Probability of normality
Advances in Mathematics, 2019 In this paper, we investigate the following question: How often is a random matrix normal? We consider a random $n\times n$ matrix, $M_n$, whose entries are i.i.d. Rademacher random variables (taking values $\{ \pm1 \}$ with probability $1/2$) and prove $$2^{-\left(0.5+o(1)\right)n^2} \le P\left(M_n \text{ is normal}\right) \le 2^{-(0.302+o(1))n^{2}}. $
Deneanu, Andrei, Vu, Van
openaire +4 more sources