Results 61 to 70 of about 129,650 (250)

Hydrodynamic Theory of the Connected Spectral form Factor

open access: yesPhysical Review X, 2022
One manifestation of quantum chaos is a random-matrix-like fine-grained energy spectrum. Prior to the inverse level spacing time, random matrix theory predicts a “ramp” of increasing variance in the connected part of the spectral form factor. However, in
Michael Winer, Brian Swingle
doaj   +1 more source

Raney Distributions and Random Matrix Theory [PDF]

open access: yesJournal of Statistical Physics, 2014
Recent works have shown that the family of probability distributions with moments given by the Fuss-Catalan numbers permit a simple parameterized form for their density. We extend this result to the Raney distribution which by definition has its moments given by a generalization of the Fuss-Catalan numbers.
Forrester, PJ, Liu, D-Z
openaire   +3 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

The geometry of evolved community matrix spectra

open access: yesScientific Reports, 2022
Random matrix theory has been applied to food web stability for decades, implying elliptical eigenvalue spectra and that large food webs should be unstable.
Silja Borring Låstad, Jan O. Haerter
doaj   +1 more source

Gravity without averaging

open access: yesSciPost Physics, 2022
We present a gravitational theory that interpolates between JT gravity, and a gravity theory with a fixed boundary Hamiltonian. For this, we consider a matrix integral with the insertion of a Gaussian with variance $\sigma^2$, centered around a matrix
Andreas Blommaert, Jorrit Kruthoff
doaj   +1 more source

Proof methods in random matrix theory

open access: yesProbability Surveys, 2023
In this survey article, we give an introduction to two methods of proof in random matrix theory: The method of moments and the Stieltjes transform method. We thoroughly develop these methods and apply them to show both the semicircle law and the Marchenko-Pastur law for random matrices with independent entries.
Fleermann, Michael, Kirsch, Werner
openaire   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

N $$ \mathcal{N} $$ = 2 JT supergravity and matrix models

open access: yesJournal of High Energy Physics, 2023
Generalizing previous results for N $$ \mathcal{N} $$ = 0 and N $$ \mathcal{N} $$ = 1, we analyze N $$ \mathcal{N} $$ = 2 JT supergravity on asymptotically AdS2 spaces with arbitrary topology and show that this theory of gravity is dual, in a holographic
Gustavo J. Turiaci, Edward Witten
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

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