Results 61 to 70 of about 128,402 (249)
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Ensemble averaging in JT gravity from entanglement in Matrix Quantum Mechanics
Journal of High Energy Physics, 2023 We consider the generalization of a matrix integral with arbitrary spectral curve ρ 0(E) to a 0+1D theory of matrix quantum mechanics (MQM). Using recent techniques for 1D quantum systems at large-N, we formulate a hydrodynamical effective theory for the
Gabriele Di Ubaldo, Giuseppe Policastro
doaj +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin +3 more
wiley +1 more source
Random matrix theory in statistics: A review [PDF]
Journal of Statistical Planning and Inference, 2014 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Paul, Debashis, Aue, Alexander
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FEBS Open Bio, EarlyView.In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin +12 more
wiley +1 more source
PDE Methods in Random Matrix Theory [PDF]
, 2020 This article begins with a brief review of random matrix theory, followed by a discussion of how the large-$N$ limit of random matrix models can be realized using operator algebras. I then explain the notion of "Brown measure," which play the role of the eigenvalue distribution for operators in an operator algebra.
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Random matrix theory and quantum chromodynamics [PDF]
, 2017 Abstract This chapter was originally presented to a mixed audience of physicists and mathematicians with some basic working knowledge of random matrix theory. The first part is devoted to the solution of the chiral Gaussian unitary ensemble in the presence of characteristic polynomials, using orthogonal polynomial techniques.
Akemann, Gernot +5 more
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Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells
FEBS Open Bio, EarlyView.To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai +8 more
wiley +1 more source