Results 81 to 90 of about 942,754 (267)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Grounding the randomness of quantum measurement [PDF]
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2016 Julian Schwinger provided to physics a mathematical reconstruction of quantum mechanics on the basis of the characteristics of sequences of measurements occurring at the atomic level of physical structure. The central component of this reconstruction is an algebra of symbols corresponding to quantum measurements, conceived of as discrete ...
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Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Convergence in Distribution of Random Measures
The Annals of Mathematical Statistics, 1972 Let $(S, \mathscr{I})$ be a measurable space, $M$ the set of all finite measures on $\mathscr{I}, \mathscr{F}_M$ the $\sigma$-algebra generated by the family of all measurable cylindrical sets $\cap^k_{i=1} \{\mu \in M: \mu(A_i) \leqq a_i\}$. With each probability measure $P$ on $\mathscr{F}_M$ the family $\{P_{A_1}, \cdots, A_k\}$ of all finite ...
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The mutual affinity of random measures
Periodica Mathematica Hungarica, 2003 We consider a set of probability measures on a finite event space $Ω$. The mutual affinity is introduced in terms of the spectrum of the associated Gram matrix. We show that, for randomly chosen measures, the empirical eigenvalue distribution of the Gram matrix converges to a fixed distribution in the limit where the number of measures, together with ...
Mark Fannes, Pascal Spincemaille
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Permutation Entropy for Random Binary Sequences
Entropy, 2015 In this paper, we generalize the permutation entropy (PE) measure to binary sequences, which is based on Shannon’s entropy, and theoretically analyze this measure for random binary sequences.
Lingfeng Liu +3 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
On Symmetrically Distributed Random Measures [PDF]
Transactions of the American Mathematical Society, 1975 A random measure ξ \xi defined on some
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