Results 101 to 110 of about 4,252,902 (288)
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Efficient sampling of random permutations
Journal of Discrete Algorithms, 2008 We show how to uniformly distribute data at random (not to be confounded with permutation routing) in two settings that are able to deal with massive data: coarse grained parallelism and external memory. In contrast to previously known work for parallel setups, our method is able to fulfill the three criteria of uniformity, work-optimality and balance ...
openaire +2 more sources
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Variable Step Sizes for Iterative Jacobian-Based Inverse Kinematics of Robotic Manipulators
IEEE AccessThis study evaluates the impact of step size selection on Jacobian-based inverse kinematics (IK) for robotic manipulators. Although traditional constant step size approaches offer simplicity, they often exhibit limitations in convergence speed and ...
Jacinto Colan +2 more
doaj +1 more source
Estimators in simple random sampling: Searls approach [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2013 This paper investigates four new estimators in simple random sampling: biased sample mean, ratio estimator and two linear regression estimators, using known coefficients of variation of the study variable and auxiliary variable. The properties of the new
Jirawan Jitthavech +1 more
doaj
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Enhancement of English-Bengali Machine Translation Leveraging Back-Translation
Applied SciencesAn English-Bengali machine translation (MT) application can convert an English text into a corresponding Bengali translation. To build a better model for this task, we can optimize English-Bengali MT.
Subrota Kumar Mondal +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source