Results 61 to 70 of about 4,872,287 (279)
Learning to Guide Random Search
CoRR, 2020 We are interested in derivative-free optimization of high-dimensional functions. The sample complexity of existing methods is high and depends on problem dimensionality, unlike the dimensionality-independent rates of first-order methods. The recent success of deep learning suggests that many datasets lie on low-dimensional manifolds that can be ...
Ozan Sener, Vladlen Koltun
openaire +4 more sources
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Random number generation and working memory. [PDF]
, 2007 We demonstrate the close relationship that exists between random sequence generation and working memory functioning. We clarify the nature of this link by examining the impact of concurrent requirements for random sequence response quality.
Towse, John N., Cheshire, Andrea
core +4 more sources
Similarity Search Based on Random Projection for High Frequency Time Series
, 2008 Similarity search in high frequency time series of domains as diverse as finance, marketing and industry has attracted much research attention recently. The main notions used in similarity search for time series are defined in a formal way.
Wu W(吴薇) +3 more
core +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Optimization and Assessment of Wavelet Packet Decompositions with Evolutionary Computation
EURASIP Journal on Advances in Signal Processing, 2003 In image compression, the wavelet transformation is a state-of-the-art component. Recently, wavelet packet decomposition has received quite an interest.
Schell Thomas, Uhl Andreas
doaj +1 more source
Relational random forests based on random relational rules [PDF]
, 2009 Random Forests have been shown to perform very well in propositional learning. FORF is an upgrade of Random Forests for relational data. In this paper we investigate shortcomings of FORF and propose an alternative algorithm, R⁴F, for generating Random ...
Pfahringer, Bernhard, Anderson, Grant
core +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Four-factor computing experiment for the random walk on a two-dimensional square field [PDF]
Компьютерные исследования и моделирование, 2017 Nowadays the random search became a widespread and effective tool for solving different complex optimization and adaptation problems. In this work, the problem of an average duration of a random search for one object by another is regarded, depending on ...
Olga Vladimirovna Maksimova +1 more
doaj +1 more source