Results 91 to 100 of about 4,872,287 (279)

Random Search Plus: A more effective random search for machine learning hyperparameters optimization [PDF]

open access: yes, 2020
Machine learning hyperparameter optimization has always been the key to improve model performance. There are many methods of hyperparameter optimization.
Li, Bohan
core  

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

open access: yesFEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss   +7 more
wiley   +1 more source

Distribution Endpoint Estimation Assessment for the use in Metaheuristic Optimization Procedure

open access: yesMendel, 2018
Metaheuristic algorithms are often applied to numerous optimization problems, involving large-scale and mixed-integer instances, specifically. In this contribution we discuss some refinements from the extreme value theory to the lately proposed ...
Jan Holesovky
doaj   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

open access: yesFEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo   +4 more
wiley   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

open access: yesFEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Statistics of Global Stochastic Optimisation: How Many Steps to Hit the Target?

open access: yesMathematics
Random walks are considered in a one-dimensional monotonously decreasing energy landscape. To reach the minimum within a region Ωϵ, a number of downhill steps have to be performed.
Godehard Sutmann
doaj   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

open access: yesFEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta   +7 more
wiley   +1 more source

OAS-XGB: An OptiFlect Adaptive Search Optimization Framework Using XGBoost to Predict Length of Stay for CAD Patients

open access: yesIEEE Access
Accurately predicting the length of hospital stay for patients with coronary artery disease is important for effective healthcare resource management and enhancing patient outcomes.
Geetha Pratyusha Miriyala   +1 more
doaj   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

open access: yesFEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey   +4 more
wiley   +1 more source

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