Results 111 to 120 of about 5,098,223 (303)
OPRA-RS: A Hearing-Aid Fitting Method Based on Automatic Speech Recognition and Random Search. [PDF]
Front Neurosci, 2022 Gonçalves Braz L +4 more
europepmc +1 more source
A minimal cellulosome‐like system in Cellulosilyticum lentocellum
FEBS Open Bio, EarlyView.Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan +2 more
wiley +1 more source
Random Search as a Neural Network Optimization Strategy for Convolutional-Neural-Network (CNN)-based Noise Reduction in CT. [PDF]
Proc SPIE Int Soc Opt Eng, 2021 Huber NR +6 more
europepmc +1 more source
FEBS Open Bio, EarlyView.The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
, 2008 In this project we designed and developed improvements for the random search algorithm UCT with a focus on improving performance with directed acyclic graphs and groupings.
Childs, Benjamin Edward +1 more
core +2 more sources
Aging and Cancer, EarlyView.Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi +3 more
wiley +1 more source
APPLICATION OF ITERATIVE DYNAMIC PROGRAMMING TO OPTIMAL FEED-BACK CONTROL PROBLEM
Научный вестник МГТУ ГА, 2016 This paper presents a generalization of iterative dynamic programming using Luus-Jakola optimization procedure applied to the solution of optimal feed-back control for nonlinear deterministic systems. Iterative dynamic programming is realized. Efficiency
A. V. Panteleev, D. A. Rodionova
doaj
An Optimized Step-Size Random Search (OSSRS)
, 1979 A random search method, Optimized Step-Size Random Search (OSSRS), for function minimization is proposed. In this method the step-size is determined by fitting a quadratic for the function value in terms of the step-size in each of the random directions.
Sheela, BV
core
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit +11 more
wiley +1 more source