Results 111 to 120 of about 4,448,600 (255)

The Search for Constrained Random Generators

Proceedings of the ACM on Programming Languages
Among the biggest challenges in property-based testing (PBT) is the constrained random generation problem: given a predicate on program values, randomly sample from the set of all values, and only values, satisfying that predicate. Efficient solutions to this problem are critical, since the executable specifications used by PBT often ...
Harrison Goldstein, Hila Peleg, Cassia Torczon, Daniel Sainati, Leonidas Lampropoulos, Benjamin C. Pierce   +5 more
openaire   +3 more sources

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Random Search Algorithms

, 2008
In this project we designed and developed improvements for the random search algorithm UCT with a focus on improving performance with directed acyclic graphs and groupings.
Childs, Benjamin Edward, Brodeur, James H.   +1 more
core   +2 more sources

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Stochastic Optimization with Random Search

CoRR
We revisit random search for stochastic optimization, where only noisy function evaluations are available. We show that the method works under weaker smoothness assumptions than previously considered, and that stronger assumptions enable improved guarantees. In the finite-sum setting, we design a variance-reduced variant that leverages multiple samples
Chayti, El Mahdi, Kadi, Taha El Bakkali El, Saadi, Omar, Jaggi, Martin   +3 more
openaire   +3 more sources

An Optimized Step-Size Random Search (OSSRS)

, 1979
A random search method, Optimized Step-Size Random Search (OSSRS), for function minimization is proposed. In this method the step-size is determined by fitting a quadratic for the function value in terms of the step-size in each of the random directions.
Sheela, BV
core  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

APPLICATION OF ITERATIVE DYNAMIC PROGRAMMING TO OPTIMAL FEED-BACK CONTROL PROBLEM

Научный вестник МГТУ ГА, 2016
This paper presents a generalization of iterative dynamic programming using Luus-Jakola optimization procedure applied to the solution of optimal feed-back control for nonlinear deterministic systems. Iterative dynamic programming is realized. Efficiency
A. V. Panteleev, D. A. Rodionova
doaj  

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source