Results 121 to 130 of about 12,241,994 (329)
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
APPLICATION OF HYBRID RANDOM SEARCH METHOD TO OPTIMISATION OF ENGINEERING SYSTEMS’ PARAMETERS
Научный вестник МГТУ ГА, 2018 This paper presents a modification of the Luus-Jaakola global optimization method, which belongs to the class of metaheuristic algorithms. A hybrid method is suggested, using a combination of random search methods: Luus-Jaakola method, adaptive random ...
A. V. Panteleev, D. A. Rodionova
doaj +1 more source
The Search for Constrained Random Generators
Proceedings of the ACM on Programming LanguagesAmong the biggest challenges in property-based testing (PBT) is the constrained random generation problem: given a predicate on program values, randomly sample from the set of all values, and only values, satisfying that predicate. Efficient solutions to this problem are critical, since the executable specifications used by PBT often ...
Harrison Goldstein +5 more
openaire +3 more sources
Aging and Cancer, EarlyView.Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi +3 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit +11 more
wiley +1 more source
Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane +10 more
wiley +1 more source
APPLICATION OF ITERATIVE DYNAMIC PROGRAMMING TO OPTIMAL FEED-BACK CONTROL PROBLEM
Научный вестник МГТУ ГА, 2016 This paper presents a generalization of iterative dynamic programming using Luus-Jakola optimization procedure applied to the solution of optimal feed-back control for nonlinear deterministic systems. Iterative dynamic programming is realized. Efficiency
A. V. Panteleev, D. A. Rodionova
doaj
Long‐Term Neurologic Exam Findings in People Diagnosed and Treated During Acute HIV Infection
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Evaluate clinical and laboratory correlates of abnormal neurologic exam findings after acute HIV infection (AHI). Methods Participants from the RV254/SEARCH 010 cohort in Bangkok underwent standardized neurologic examinations at Weeks 0 (AHI), 12, 96, and 288 following antiretroviral therapy (ART).
Kathryn B. Holroyd +118 more
wiley +1 more source
, 2009 Random search algorithms are useful for many ill-structured global optimization problems with continuous and/or discrete variables. Typically random search algorithms sacrifice a guarantee of optimality for finding a good solution quickly with ...
Zelda B. Zabinsky
core