Results 81 to 90 of about 5,098,223 (303)

Hyperconical Random Search

, 1972
The rate of convergence of a multidimensional random search is found to improve when the search region is restricted to a directed adaptive hypercone.
M. J. Wozny, G. T. Heydt
core   +1 more source

Visual search in ecological and non-ecological displays: Evidence for a non-monotonic effect of complexity on performance [PDF]

, 2012
Copyright @ 2013 PLoSThis article has been made available through the Brunel Open Access Publishing Fund.Considerable research has been carried out on visual search, with single or multiple targets. However, most studies have used artificial stimuli with
Philippe Chassy, Fernand Gobet, Chassy, P, Chassy, Philippe, Gobet Fernand, Gobet, Fernand, Chassy Philippe, Gobet, F   +7 more
core   +2 more sources

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Feature Selection as a Time and Cost-Saving Approach for Land Suitability Classification (Case Study of Shavur Plain, Iran)

Agriculture, 2016
Land suitability classification is important in planning and managing sustainable land use. Most approaches to land suitability analysis combine a large number of land and soil parameters, and are time-consuming and costly.
Saeid Hamzeh, Marzieh Mokarram, Azadeh Haratian, Harm Bartholomeus, Arend Ligtenberg, Arnold K. Bregt   +5 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Optimizing XGBoost for Heart Disease Risk Classification Using Optuna and Random Search on the Behavioral Risk Factor Surveillance System (BRFSS) 2023 Dataset

Journal of Applied Informatics and Computing
Heart disease is a critical public health issue in Indonesia, contributing to approximately 1,5 million deaths annually. Although machine learning methods, particularly Extreme Gradient Boosting (XGBoost), have demonstrated strong performance in medical ...
Muhammad Dzaky, Adam Prayogo Kuncoro, Riyanto Riyanto   +2 more
doaj   +1 more source

Honey Bees Inspired Optimization Method: The Bees Algorithm

Insects, 2013
Optimization algorithms are search methods where the goal is to find an optimal solution to a problem, in order to satisfy one or more objective functions, possibly subject to a set of constraints.
Ernesto Mastrocinque, Alfredo Lambiase, Duc Truong Pham, Baris Yuce, Michael S. Packianather   +4 more
doaj   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Hyperparameters tuning of random forest with harmony search in credit scoring [PDF]

, 2019
Correct identification of defaulters and non-defaulters in the lending industry is a crucial task for financial institutions. Credit scoring is a tool utilized for credit granting decisions.
Goh, Rui Ying, Adam, Mohd. Bakri, Lee, Lai Soon   +2 more
core   +1 more source

Randomized Ternary Search Tries

CoRR, 2016
This paper presents a new kind of self-balancing ternary search trie that uses a randomized balancing strategy adapted from Aragon and Seidel's randomized binary search trees ("treaps"). After any sequence of insertions and deletions of strings, the tree looks like a ternary search trie built by inserting strings in random order.
openaire   +3 more sources