Results 41 to 50 of about 609,466 (311)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
An Optimized Hyperparameter Tuning for Improved Hate Speech Detection with Multilayer Perceptron
Jurnal RESTI (Rekayasa Sistem dan Teknologi Informasi)Hate speech classification is a critical task in the domain of natural language processing, aiming to mitigate the negative impacts of harmful content on digital platforms.
Muhamad Ridwan, Ema Utami
doaj +1 more source
Journal of Taibah University for Science, 2019 We present the existence of a finite search plan to find Brownian target on the d-space by using d-searchers. Each searcher moves continuously in both directions of the origin (starting point) of the line (field of its search) with random distances and ...
Mohamed Abd Allah El-Hadidy +1 more
doaj +1 more source
Learning to Guide Random Search
CoRR, 2020 We are interested in derivative-free optimization of high-dimensional functions. The sample complexity of existing methods is high and depends on problem dimensionality, unlike the dimensionality-independent rates of first-order methods. The recent success of deep learning suggests that many datasets lie on low-dimensional manifolds that can be ...
Ozan Sener, Vladlen Koltun
openaire +3 more sources
Towards large scale continuous EDA: a random matrix theory perspective
, 2013 Estimation of distribution algorithms (EDA) are a major branch of evolutionary algorithms (EA) with some unique advantages in principle. They are able to take advantage of correlation structure to drive the search more efficiently, and they are able to ...
Kabán, Ata +5 more
core +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Theory of Randomized Search Heuristics [PDF]
Algorithmica, 2012 Randomized search heuristics such as evolutionary algorithms, evolution strategies, ant colony optimizers etc. are optimization algorithms that can be applied to a wide class of problems ranging from combinatorial to continuous optimization. They are popular in practice because they are generally easy to implement, their application requires little ...
Anne Auger, Carsten Witt
openaire +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Optimization Algorithm for Cutting Masonry with a Robotic Saw
Applied SciencesThe contribution of this study is in the novel application of the bin packing algorithm that is used to optimize the robotic bricklaying process with the aim of minimizing the wearing of a robotic saw used for splitting brick blocks so as to minimize ...
Vjačeslav Usmanov +3 more
doaj +1 more source
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source