Results 41 to 50 of about 4,872,287 (279)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
An Optimized Hyperparameter Tuning for Improved Hate Speech Detection with Multilayer Perceptron
Jurnal RESTI (Rekayasa Sistem dan Teknologi Informasi)Hate speech classification is a critical task in the domain of natural language processing, aiming to mitigate the negative impacts of harmful content on digital platforms.
Muhamad Ridwan, Ema Utami
doaj +1 more source
Journal of Taibah University for Science, 2019 We present the existence of a finite search plan to find Brownian target on the d-space by using d-searchers. Each searcher moves continuously in both directions of the origin (starting point) of the line (field of its search) with random distances and ...
Mohamed Abd Allah El-Hadidy +1 more
doaj +1 more source
Research on stock trend prediction method based on optimized random forest
CAAI Transactions on Intelligence Technology, 2023 As a complex hot problem in the financial field, stock trend forecasting uses a large amount of data and many related indicators; hence it is difficult to obtain sustainable and effective results only by relying on empirical analysis.
Lili Yin +3 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Modeling a random search [PDF]
, 1975 A model for random search is considered which differs from the classical random search by modeling the random paths of the searcher and/or target as those of a Wiener process.
Shubert, Bruno O.
core +2 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Optimization Algorithm for Cutting Masonry with a Robotic Saw
Applied SciencesThe contribution of this study is in the novel application of the bin packing algorithm that is used to optimize the robotic bricklaying process with the aim of minimizing the wearing of a robotic saw used for splitting brick blocks so as to minimize ...
Vjačeslav Usmanov +3 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source