Results 81 to 90 of about 11,404,815 (245)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Krylov complexity of supersymmetric SYK models
Journal of High Energy PhysicsWe study the effect of supersymmetry breaking on Krylov complexity in the N = 2 $$ \mathcal{N}=2 $$ SYK model under irrelevant and mass deformations of the Hamiltonian. The irrelevant deformation breaks N = 2 $$ \mathcal{N}=2 $$ supersymmetry down to N =
James Chryssanthacopoulos, David Vegh
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Non-Abelian entanglement asymmetry in random states
Journal of High Energy PhysicsThe entanglement asymmetry measures the extent to which a symmetry is broken within a subsystem of an extended quantum system. Here, we analyse this quantity in Haar random states for arbitrary compact, semi-simple Lie groups, building on and ...
Angelo Russotto +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Annealed and quenched limit theorems for random expanding dynamical systems
, 2015 We present results concerning annealed and quenched limit theorems for random expanding dynamical systems. In particular we will present results on annealed and quenched versions of a central limit theorem, a large deviation principle, a local limit ...
Nicol, Matthew
core +1 more source
The emergence of waves in random discrete systems
Scientific Reports, 2016 Essential criteria for the emergence of wave-like manifestations occurring in an entirely discrete system are identified using a simple model for the movement of particles through a network. The dynamics are entirely stochastic and memoryless involving a
John Pickton +2 more
doaj +1 more source