Results 201 to 210 of about 5,579,561 (370)
Advanced Science, EarlyView.Testosterone enhances Aβ‐induced autophagy in microglia via the non‐genomic testosterone receptor GPRC6A, promoting Aβ clearance by suppressing ERK phosphorylation and inhibiting mTOR activation. In male 5xFAD mice, testicular removal reduces microglial autophagy and Aβ clearance, which is restored by testosterone.
Haiyan Du +8 more
wiley +1 more source
Phylogenetic tree of the australian species of Nicotiana based on the random amplified polymorphic DNA [PDF]
, 2001 Slavko Komarnytsky, I. K. Komarnytsky
openalex +1 more source
Machine Learning‐Enabled Drug‐Induced Toxicity Prediction
Advanced Science, EarlyView.Unexpected toxicity accounts for 30% of drug development failures. This review highlights ML innovations in predicting drug‐induced toxicity, emphasizing comparative analyses, interpretable algorithms, and multi‐source data integration. It categorizes toxicity types, summarizes ML models, and organizes key databases, offering strategies to address ...
Changsen Bai +5 more
wiley +1 more source
Flowsheet generation through hierarchical reinforcement learning and graph neural networks
AIChE Journal, Volume 69, Issue 1, January 2023., 2023 Abstract Process synthesis experiences a disruptive transformation accelerated by artificial intelligence. We propose a reinforcement learning algorithm for chemical process design based on a state‐of‐the‐art actor‐critic logic. Our proposed algorithm represents chemical processes as graphs and uses graph convolutional neural networks to learn from ...
Laura Stops +3 more
wiley +1 more source
Advanced Science, EarlyView.In this study, a comprehensive single‐cell transcriptome atlas of the Dezhou donkey, encompassing 20 tissues and 275 050 cells, is constructed. Through cross‐species and cross‐tissue analyses, distinct transcriptional patterns in donkey sebocytes are identified.
Yu Tian +11 more
wiley +1 more source
Robotic Active Information Gathering for Spatial Field Reconstruction with Rapidly-Exploring Random Trees and Online Learning of Gaussian Processes. [PDF]
Sensors (Basel), 2019 Viseras A, Shutin D, Merino L.
europepmc +1 more source
Signatures of Random and Selective Mass Extinctions in Phylogenetic Tree Balance [PDF]
, 2002 Stephen B. Heard, Arne Ø. Mooers
openalex +1 more source
Uncover Hidden Physical Information of Soft Matter by Observing Large Deformation
Advanced Science, EarlyView.Detecting internal abnormalities in soft matter remains challenging due to its heterogeneous nature. This study introduces a method that infers hidden physical properties by matching observed deformation with simulation through parallel Bayesian optimization.
Huanyu Yang +9 more
wiley +1 more source