Results 211 to 220 of about 5,474,085 (350)

Novel ATR/PARP1 Dual Inhibitors Demonstrate Synergistic Antitumor Efficacy in Triple‐Negative Breast Cancer Models

Advanced Science, EarlyView.
Novel ATR/PARP1 dual inhibitors are developed for the first time. Advanced lead B8 effectively reduces cell viability in vitro and suppresses tumor growth in vivo, with better potency than ATRi and PARPi alone or in combination. Mechanistically, B8 induces apoptosis, arrests the cell cycle, and inhibits cancer cells colony formation, migration, and ...
Yuan Gao, Jiawei Zhou, Chen‐Chen Wang, Zong‐Hao Wang, Nian‐Dong Mao, Meng‐Lan He, Peng‐Peng Zhang, Ping Huang, Guo‐Wei Ye, Yu‐Qing Zhang, Feng‐Hui Tang, Hang Zhang, Tian Xie, Xiang‐Yang Ye   +13 more
wiley   +1 more source

Asymptotic degree distribution in random recursive trees [PDF]

, 2004
Svante Janson
openalex   +1 more source

MARRT: Medial Axis biased rapidly-exploring random trees

IEEE International Conference on Robotics and Automation, 2014
Jory Denny, Evan Greco, Shawna L. Thomas, N. Amato   +3 more
semanticscholar   +1 more source

Long Term High‐Salt Diet Induces Cognitive Impairments via Down‐Regulating SHANK1

Advanced Science, EarlyView.
The study identifies a novel mechanistic link between long‐term HS diet and cognitive impairment, wherein PKA/CREB axis inactivation leads to SHANK1 reduction, synaptic damage, and cognitive deficits. Abstract High‐salt (HS) diet is an established risk factor for cognitive impairment, but the underlying mechanisms remain unclear.
Cuiping Guo, Yuanyuan Li, Wensheng Li, Tongrui Wu, Yi Liu, Yacoubou Abdoul Razak Mahaman, Jianzhi Wang, Rong Liu, Wei Liu, Hui Shen, Xiaochuan Wang   +10 more
wiley   +1 more source

The exploration process of inhomogeneous continuum random trees, and an extension of Jeulin’s local time identity [PDF]

, 2004
David Aldous, Grégory Miermont, Jim Pitman   +2 more
openalex   +1 more source

Deciphering Cell Type Abundance in Proteomics Data Through Graph Neural Networks

Advanced Science, EarlyView.
GraphDEC constructs pseudo bulk reference data using a mixup strategy, then learns low dimensional representations via autoencoders to model intra and inter dataset relationships. These are processed through a multi view adaptive neighborhood aware GNN, integrating reference, target, and joint graphs.
Zhiming Dai, Yujie Song, Tuoshi Qi, Hongyu Zhang, Huiying Zhao, Zheng Wang, Yuedong Yang, Yuansong Zeng   +7 more
wiley   +1 more source

The size of random bucket trees via urn models [PDF]

, 2004
Hosam M. Mahmoud
openalex   +1 more source

deepTFBS: Improving within‐ and Cross‐Species Prediction of Transcription Factor Binding Using Deep Multi‐Task and Transfer Learning

Advanced Science, EarlyView.
DeepTFBS leverages deep learning to predict transcription factor binding sites across species, integrating multi‐task and transfer learning approaches to improve performance in data‐scarce scenarios. This study demonstrates enhanced accuracy in intra‐ and cross‐species prediction, revealing conserved regulatory patterns and functional variants.
Jingjing Zhai, Yuzhou Zhang, Chujun Zhang, Xiaotong Yin, Minggui Song, Chenglong Tang, Pengjun Ding, Zenglin Li, Chuang Ma   +8 more
wiley   +1 more source

Development and Evaluation of Preharvest <i>Thaumatotibia leucotreta</i> Citrus Fruit Infestation Monitoring for Inclusion in a Systems Approach. [PDF]

Insects
Moore SD, Marsberg T, Peyper M, Cousins L, van der Merwe M, Sutton G, van Niekerk S, Hattingh V.   +7 more
europepmc   +1 more source

The distribution of the size of the ancestor‐tree and of the induced spanning subtree for random trees [PDF]

, 2004
Alois Panholzer
openalex   +1 more source