Results 61 to 70 of about 166,958 (306)

An Intrusion Detection Model Based on Random Tree Algorithm with Dimensionality Reduction and Oversampling

Journal of Computing and Information Technology, 2023
With the advancement of the university information process, more and more application systems are running on the campus network, and the information system becomes larger and more complex. With the rapid growth of network users and the popularization and
Li Yin, Yijun Chen
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Random ultrametric trees and applications*

ESAIM: Proceedings and Surveys, 2017
Ultrametric trees are trees whose leaves lie at the same distance from the root. They are used to model the genealogy of a population of particles co-existing at the same point in time.
Lambert Amaury
doaj   +1 more source

Predicting the Pillar Stability of Underground Mines with Random Trees and C4.5 Decision Trees

Applied Sciences, 2020
Predicting pillar stability in underground mines is a critical problem because the instability of the pillar can cause large-scale collapse hazards. To predict the pillar stability for underground coal and stone mines, two new models (random tree and C4 ...
Mahmood Ahmad, Naser A. Al-Shayea, Xiao-Wei Tang, Arshad Jamal, Hasan M. Al-Ahmadi, Feezan Ahmad   +5 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Label-based parameters in increasing trees [PDF]

Discrete Mathematics & Theoretical Computer Science, 2006
Grown simple families of increasing trees are a subclass of increasing trees, which can be constructed by an insertion process. Three such tree families contained in the grown simple families of increasing trees are of particular interest: $\textit ...
Markus Kuba, Alois Panholzer
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Random walks on trees

Discrete Mathematics, 1980
AbstractThe classical gambler's ruin problem, i.e., a random walk along a line may be viewed graph theoretically as a random walk along a path with the endpoints as absorbing states. This paper is an investigation of the natural generalization of this problem to that of a particle walking randomly on a tree with the endpoints as absorbing barriers ...
openaire   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source