Results 111 to 120 of about 3,327,271 (332)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Moments for cumulative sums of random variables [PDF]
, 1953 Karel Winkelbauer
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Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
On the Lebesgue measure of one generalised set of subsums of geometric series
Математичні СтудіїIn the present paper, we study a set that can be treated as a generalised set of subsums for a geometric series. This object was discovered independently in various mathematical aspects.
O. P. Makarchuk, D. M. Karvatskyi
doaj +1 more source
On The Quotient of a Centralized and a Non-centralized Complex Gaussian Random Variable. [PDF]
J Res Natl Inst Stand Technol, 2020 Gu D.
europepmc +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Modeling Directional Monotonicity in Sequence with Copulas
AxiomsIn this paper, we present the concept of being monotonic in sequence according to a specific direction for a collection of random variables. This concept broadens the existing notions of multivariate dependence, such as sequential left-tail and right ...
José Juan Quesada-Molina +1 more
doaj +1 more source
On the order of growth of convergent series of independent random variables [PDF]
, 2004 Eunwoo Nam
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Expected Logarithm and Negative Integer Moments of a Noncentral χ2-Distributed Random Variable. [PDF]
Entropy (Basel), 2020 Moser SM.
europepmc +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source