Results 51 to 60 of about 3,022,789 (295)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Finite element method using vector finite elements applied to eddy current problems [PDF]

, 2011
Vector fields found in electromagnetics are fundamentally different to vector fields found in other research areas such as structural mechanics. Electromagnetic vector fields possess different physical behaviour patterns and different properties in ...
Adams, Leila
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Equilibrium points of random generalized games

International Journal of Mathematics and Mathematical Sciences, 1998
In this paper, the concepts of random maximal elements, random equilibria and random generalized games are described. Secondly by measurable selection theorem, some existence theorems of random maximal elements for Lc-majorized correspondences are ...
E. Tarafdar, Xian-Zhi Yuan
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Random Vector

, 2020
U ovome radu ćemo generalizirati pojam slučajne varijable na n-dimenzionalan prostor, odnosno promatrat ćemo slučajni vektor. Poznato je da slučajnu varijablu možemo u potpunosti opisati pomoću njezine funkcije distribucije, a također ćemo pomoću ...
Kopić, Katarina
core   +2 more sources

On Vector Random Linear Network Coding in Wireless Broadcasts

Entropy
Compared with scalar linear network coding (LNC) formulated over the finite field GF(2L), vector LNC offers enhanced flexibility in the code design by enabling linear operations over the vector space GF(2)L and demonstrates a number of advantages over ...
Rina Su, Chengji Zhao, Qifu Sun, Zhongshan Zhang   +3 more
doaj   +1 more source

Solar Power Prediction via Support Vector Machine and Random Forest

E3S Web of Conferences, 2018
Due to the variability and instability of photovoltaic (PV) output, the accurate prediction of PV output power plays a major role in energy market for PV operators to optimize their profits in energy market.
Yen Chih-Feng, Hsieh He-Yen, Su Kuan-Wu, Yu Min-Chieh, Leu Jenq-Shiou   +4 more
doaj   +1 more source