Results 151 to 160 of about 703,659 (314)

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Modelling wound area in studies of wound healing interventions

BMC Medical Research Methodology
Background Experimental studies of wound healing often use survival analysis and time to event outcomes or differences in wound area at a specific time point.
Samuel I. Watson, Eleni Gkini, Jon Bishop, Katie Scandrett, Indra Napit, Richard J. Lilford   +5 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

The hazards of chasing subgroups in neutral stroke trials

Neurological Research and Practice
Background The majority of randomised controlled trials in acute stroke and many for prevention are neutral, i.e. they failed to reach statistical significance.
Philip M. Bath, George Howard, Werner Hacke   +2 more
doaj   +1 more source

Pragmatic randomised controlled trials [PDF]

Primary Care Respiratory Journal, 2002
openaire   +2 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Prostate cancer screening: Results of a prospective trial in Canton Aargau, Switzerland

Swiss Medical Weekly, 2004
M Moschopulos, K Lehmann, M Wernli, A Häfeli   +3 more
doaj   +1 more source

Pledging after nudging improves uptake of plant-based diets: a field experiment in a German university cafeteria

Environmental Research Communications
Meat-based diets are carbon-intensive and incompatible with Paris climate targets. Reducing meat consumption is essential to mitigate climate change. Behavioural nudges, which present structured choices to citizens, have been increasingly used to reduce ...
Philipp Thamer, Sanchayan Banerjee, Peter John   +2 more
doaj   +1 more source

Randomised controlled trial of azithromycin in smokers with asthma [PDF]

, 2013
Anderson, K., Cameron, E.J., Chaudhuri, R., Donnelly, I., Evans, T.J., Gallacher, K., Greenlaw, N., Jolly, L., Mair, F., McSharry, C., Morrison, D., Spears, M., Thomson, N.C, Weir, C.J.   +13 more
core   +3 more sources