Results 251 to 260 of about 1,182,141 (298)

Genetic Association Between Polymyositis/Dermatomyositis and Epilepsy: Insights From Mendelian Randomization and Bioinformatic Analyses. [PDF]

Brain Behav
Liu Y, Yu Y, Fang C, Wu Q, Ou L, Xiao J, Duan K, Jiang T, Ye L, Hu X, Feng Z.   +10 more
europepmc   +1 more source

OP0041 Treatment of primary Sjögren's disease by blocking FcRn: clinical and translational data from RHO, a phase 2 randomized, placebo controlled, double-blind, proof-of-concept study with efgartigimod

Isabelle Peene, Gwenny M. Verstappen, Joke Deprez, Frans G. M. Kroese, S. Arends, Aaron S. Kelly, L. Vandersarren, E Frances Bowen, Johannes W. G. Jacobs, Paul Meyvisch, Dirk Elewaut, Hendrika Bootsma   +11 more
openalex   +1 more source

Effectiveness and Safety of Nusinersen and Risdiplam in Spinal Muscular Atrophy: A Systematic Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinal Muscular Atrophy (SMA) is a rare genetic disorder marked by progressive muscle weakness and mobility loss. It has a profound physical, emotional and social impact on patients and caregivers, requiring comprehensive medical and supportive care.
Amin Mehrabian, Peter Auguste, Amy Grove, Anna Brown, Janette Parr, Mubarak Patel, Furqan Butt, Jeremiah Donoghue, Mehdi Yousefi, Jo Parsons   +9 more
wiley   +1 more source

Circulating metabolites on dental caries risk: A Mendelian randomization study. [PDF]

Medicine (Baltimore)
Shi P, Liu X, Lei F, Hu Z, Xu Z.
europepmc   +1 more source

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

Assessing the impact of maternal blood pressure during pregnancy on perinatal health: a wide-angled Mendelian randomization study. [PDF]

BMC Med
Morales-Berstein F, Gonçalves-Soares A, Yang Q, McBride N, Bond T, Al Arab M, Fernández-Sanlés A, Magnus MC, Sanderson E, Hart E, Fraser A, Birchenall KA, Lawlor DA, Clayton GL, Borges MC.   +14 more
europepmc   +1 more source

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

Increased Blood Levels of NfL, GFAP, and Placental Growth Factor After Radiotherapy to the Brain

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT In this study, we analyzed biomarkers of neuronal, glial, and vascular injury in longitudinal paired samples of blood and cerebrospinal fluid after prophylactic cranial irradiation in patients with small cell lung cancer. Neurofilament light chain protein (NfL) and glial fibrillary acidic protein (GFAP) increased in serum and cerebrospinal ...
Erik Fernström, Thomas Björk‐Eriksson, Pontus Erickson, Jan Nyman, Henrik Zetterberg, Marie Kalm   +5 more
wiley   +1 more source

Growth and sleep outcomes after adenotonsillectomy in pediatric mild sleep-disordered breathing. [PDF]

Sci Rep
Gong W, Huang K, Psychogios I, Li S, Chen L, Zhang J, Fang F, Zhang Z, Hu Y.   +8 more
europepmc   +1 more source

Integration of Mendelian randomization and transcriptome wide association studies for causal gene identification in ovarian cancer genetic architecture. [PDF]

Discov Oncol
Yang Q, Zeng Z, Wang J, Wei X.
europepmc   +1 more source