Results 61 to 70 of about 1,182,141 (298)

Accuracy and distribution of baseline categorical variables and p-values in spine randomized controlled trials

Royal Society Open Science
Levayer and colleagues assessed integrity issues in randomized controlled trials (RCTs) in four spine journals using baseline p-values from categorical variables, concluding that there was no evidence of ‘systemic fraudulent behaviour’.
Mark J. Bolland, Alison Avenell, Andrew Grey   +2 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Effects of Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032 on Overweight and the Gut Microbiota in Humans: Randomized, Double-Blinded, Placebo-Controlled Clinical Trial [PDF]

, 2022
Sung Joon Mo, Kippeum Lee, Hyoung-Ju Hong, Dong-Ki Hong, Seung-Hee Jung, Soo-Dong Park, Jae-Jung Shim, Jung-Lyoul Lee   +7 more
openalex   +1 more source

Typical = Random

Axioms, 2023
This expository paper advocates an approach to physics in which “typicality” is identified with a suitable form of algorithmic randomness. To this end various theorems from mathematics and physics are reviewed. Their original versions state that some property Φ(x) holds for P-almost all x∈X, where P is a probability measure on some space X.
openaire   +5 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Random brains

The 2013 International Joint Conference on Neural Networks (IJCNN), 2013
In this paper, we introduce and evaluate a novel method, called random brains, for producing neural network ensembles. The suggested method, which is heavily inspired by the random forest technique, produces diversity implicitly by using bootstrap training and randomized architectures.
Johansson, Ulf, Löfström, Tuve, Boström, Henrik   +2 more
openaire   +3 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Optimal allocation of sample size for randomization-based inference from 2K factorial designs

Journal of Causal Inference
Optimizing the allocation of units into treatment groups can help researchers improve the precision of causal estimators and decrease costs when running factorial experiments.
Ravichandran Arun, Pashley Nicole E., Libgober Brian, Dasgupta Tirthankar   +3 more
doaj   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

On random random walks [PDF]

The Annals of Probability, 1996
The author proves a symmetric analog of a theorem due to Dou and Hildebrand on the expected mixing time of certain random walks on a finite group \(G\) of order \(g\) with uniform distribution \(U\), and derives from this result good bounds on diameters of random directed Cayley graphs.
openaire   +3 more sources