Results 71 to 80 of about 1,461,213 (320)
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Random triangles in random graphs
Random Structures & Algorithms, 2021 AbstractIn a recent paper, Oliver Riordan shows that for and p up to and slightly larger than the threshold for a Kr‐factor, the hypergraph formed by the copies of Kr in G(n, p) contains a copy of the binomial random hypergraph with . For r = 3, he gives a slightly weaker result where the density in the random hypergraph is reduced by a constant ...
openaire +3 more sources
FEBS Letters, EarlyView.C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi +5 more
wiley +1 more source
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
FEBS Letters, EarlyView.Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source
Sinusoidal Seismic Noise Suppression Using Randomized Principal Component Analysis
IEEE Access, 2020 Sinusoidal interference is a common type of noise caused by power facilities. It usually has the fixed frequency and large amplitude which will have a negative impact on seismic data processing. We propose a new approach for suppressing sinusoidal noise,
Hang Wang, Hua Zhang, Yangkang Chen
doaj +1 more source
Randomized Caches Considered Harmful in Hard Real-Time Systems [PDF]
Leibniz Transactions on Embedded Systems, 2014 We investigate the suitability of caches with randomized placement and replacement in the context of hard real-time systems. Such caches have been claimed to drastically reduce the amount of information required by static worst-case execution time (WCET)
Reineke, Jan
doaj +1 more source
Journal of Computer and System Sciences, 2001 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Rodney G. Downey +2 more
openaire +4 more sources
Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM
FEBS Letters, EarlyView.Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley +1 more source
Bone & Joint OpenAims: The Bracing Adolescent Idiopathic Scoliosis (BASIS) study is a randomized controlled non-inferiority pragmatic trial of ‘full-time bracing’ (FTB) compared to ‘night-time bracing’ (NTB) for the treatment of adolescent idiopathic scoliosis (AIS). We
Frances C. Sherratt +9 more
doaj +1 more source
Stratification Trees for Adaptive Randomization in Randomized Controlled Trials
, 2020 This paper proposes an adaptive randomization procedure for two-stage randomized controlled trials. The method uses data from a first-wave experiment in order to determine how to stratify in a second wave of the experiment, where the objective is to ...
Tabord-Meehan, Max
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