Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Tree cover change detection through Artificial Neural Network classification using Landsat TM and ETM+ images (case study: Golestan Province, Iran) [PDF]
تحقیقات جنگل و صنوبر ایران, 2008 The aim of this research was to detect tree cover changes through Artificial Neural Network classification and post-classification comparison methods using landsat TM and ETM+ images in Golestan province, north of Iran with area of 20437.74 ha. Land uses
Abdorrasool Salman Mahini +3 more
doaj
Characterization of Mutational Tolerance of a Viral RNA–Protein Interaction
Viruses, 2019 Replication of RNA viruses is generally markedly error-prone. Nevertheless, these viruses usually retain their identity under more or less constant conditions due to different mechanisms of mutation tolerance.
Maria A. Prostova +8 more
doaj +1 more source
Intrinsic randomness as a measure of quantum coherence [PDF]
, 2015 Xiao Yuan +3 more
openalex +1 more source
Comparison of the Efficacy of HSK3486 and Propofol for Induction of General Anesthesia in Adults: A Multicenter, Randomized, Double-blind, Controlled, Phase 3 Noninferiority Trial [PDF]
, 2023 Tong J. Gan +9 more
openalex +1 more source
Molecular Oncology, EarlyView.Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande +11 more
wiley +1 more source
Efficacy and safety of darbepoetin alfa in anaemic patients with lymphoproliferative malignancies: a randomized, double‐blind, placebo‐controlled study [PDF]
, 2003 Michael Hedenus +13 more
openalex +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Enhancing Agricultural Extension Programs: A Practical Guide to Designing and Implementing Randomized Controlled Trials [PDF]
مجلة جامعة النجاح للأبحاث العلوم الطبيعيةEvidence-based practices in agricultural extension programs must be guided by precise evaluation strategies and reliable data. Methods like randomized controlled trials (RCTs) are vital for assessing specific program interventions.
Amin ABU-ALSOUD +2 more
doaj +1 more source