Results 61 to 70 of about 114,115 (267)

An introduction to randomized algorithms

open access: yesDiscrete Applied Mathematics, 1991
The concept of randomization is known to be an extremely important tool for the design of algorithms. Its use often yields better time or space complexity compared with the best deterministic algorithms we know of for the same problem; moreover resulting randomized algorithms are often very simple to understand and implement.
openaire   +1 more source

A randomized maximum-flow algorithm [PDF]

open access: yes30th Annual Symposium on Foundations of Computer Science, 1989
Summary: A randomized algorithm for computing a maximum flow is presented. For an \(n\)-vertex \(m\)-edge network, the running time is \(O(nm + n^2 (\log n)^2)\) with probability at least \(1 - 2^{- \sqrt {nm}}\). The algorithm is always correct, and in the worst case runs in \(O(nm \log n)\) time.
Cheriyan, J., Hagerup, T.
openaire   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

A Monad for Randomized Algorithms

open access: yesElectronic Notes in Theoretical Computer Science, 2016
AbstractIn this paper, we introduce a monad of random choice for domains that does not suffer from the main two drawbacks of the probabilistic powerdomain. It is not known whether any Cartesian closed category of domains is closed under the probabilistic powerdomain, but the Cartesian closed category BCD is closed under this monad of random choice ...
openaire   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

An accelerated randomized Kaczmarz algorithm [PDF]

open access: yesMathematics of Computation, 2015
The randomized Kaczmarz ( R K \rm {RK} )
Ji Liu 0002, Stephen J. Wright 0001
openaire   +3 more sources

On the Use of Biased-Randomized Algorithms for Solving Non-Smooth Optimization Problems

open access: yesAlgorithms, 2019
Soft constraints are quite common in real-life applications. For example, in freight transportation, the fleet size can be enlarged by outsourcing part of the distribution service and some deliveries to customers can be postponed as well; in inventory ...
Angel Alejandro Juan   +4 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Do Randomized Algorithms Improve the Efficiency of Minimal Learning Machine?

open access: yesMachine Learning and Knowledge Extraction, 2020
Minimal Learning Machine (MLM) is a recently popularized supervised learning method, which is composed of distance-regression and multilateration steps. The computational complexity of MLM is dominated by the solution of an ordinary least-squares problem.
Joakim Linja   +3 more
doaj   +1 more source

Home - About - Disclaimer - Privacy