Results 61 to 70 of about 2,737,426 (261)

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Randomized Estimation for Low-Light Imaging With Unknown-but-Bounded Noise

IEEE Access
This paper addresses parameter estimation in low-light imaging when the number of observations is limited and the dominant uncertainty is unknown-but-bounded dark noise.
Konstantin Amelin, Victoria Erofeeva, Oleg Granichin, Irina Len   +3 more
doaj   +1 more source

Algorithms with greedy heuristic procedures for mixture probability distribution separation [PDF]

Yugoslav Journal of Operations Research, 2019
For clustering problems based on the model of mixture probability distribution separation, we propose new Variable Neighbourhood Search algorithms (VNS) and evolutionary genetic algorithms (GA) with greedy agglomerative heuristic procedures and compare ...
Kazakovtsev Lev, Stashkov Dmitry, Gudyma Mikhail, Kazakovtsev Vladimir   +3 more
doaj   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Randomized competitive algorithms for successful and unsuccessful search

, 1996
This paper studies the classical dictionary problem using a self-adjusting linear list. We designed and analyzed randomized, on-line algorithms for a sequence of successful and unsuccessful searches which are competitive with off-line algorithms.
Hui, LCK, Martel, CU
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

A Framework for Statistical Inference via Randomized Algorithms [PDF]

, 2023
Randomized algorithms, such as randomized sketching or projections, are a promising approach to ease the computational burden in analyzing large datasets.
Zhang, Zhixiang, Lee, Sokbae, Dobriban, Edgar   +2 more
core   +1 more source

Notes on Randomized Algorithms [PDF]

Lecture notes for the Yale Computer Science course CPSC 469/569 Randomized Algorithms. Suitable for use as a supplementary text for an introductory graduate or advanced undergraduate course on randomized algorithms.
Aspnes, James
core