Results 181 to 190 of about 1,015,895 (316)

A randomized, double-blind, placebo-controlled trial to evaluate the efficacy, safety, tolerability, and pharmacokinetic/pharmacodynamic effects of a targeted exposure of intravenous repinotan in patients with acute ischemic stroke: modified Randomized Exposure Controlled Trial (mRECT)

, 2009
Hacke W, Lyden PD, Bayer HealthCare AG, MARINI, Carmine, Teal P, Davis S, Fierus M, Modified Randomized Exposure Controlled Trial Study Investigators, Kaste M   +8 more
core   +2 more sources

Lumbar Microdiscectomy and Postoperative Activity Restrictions: A Randomized Controlled Trial. [PDF]

Spine (Phila Pa 1976)
Roadley J, Daly C, Rogers M, Danks RA, Sher I, Kam J, Castle-Kirszbaum M, Ayton S, Fryer K, Risbey P, Goldschlager T.   +10 more
europepmc   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Acupuncture for Early Parkinson's Motor Symptoms: A Multicenter Randomized Controlled Trial Protocol. [PDF]

Neuropsychiatr Dis Treat
Zhang J, Xie Y, Huang W, Wu J, Feng L, Li H, Jia X, Zhang X, Tang X, Yu F, Dong Z, Cui S, Liu W, Zhu X, Guo Z, Xu N, Wang L.   +16 more
europepmc   +1 more source

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

Home-Based RESIST: Rationale and Design of a Multicenter Randomized Controlled Trial. [PDF]

J Am Heart Assoc
Zhang W, Liu Y, Zhang W, Jia X, Yu E, Yao L, Ma Z, Zhu D, Ya N, Wu S, He Y, Song Z, Hou C, Ji X, Wu C.   +14 more
europepmc   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Electroacupuncture for treating the cognitive symptoms of Alzheimer's disease: a randomized controlled trial. [PDF]

Front Psychiatry
Li R, Chen Z, Jiang Y, Yan S, He J, Yan J, Zong G, Yi Z, Ren X, Jia B.   +9 more
europepmc   +1 more source

Impact of Asymptomatic Intracranial Hemorrhage on Outcome After Endovascular Stroke Treatment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Endovascular treatment (EVT) achieves high rates of recanalization in acute large‐vessel occlusion (LVO) stroke, but functional recovery remains heterogeneous. While symptomatic intracranial hemorrhage (sICH) has been well studied, the prognostic impact of asymptomatic intracranial hemorrhage (aICH) after EVT is less certain ...
Shihai Yang, Chengsong Yue, Zhuang Li, Xiaolei Shi, Haoxuan Zhu, Jie Yang, Linyu Li, Jiaxing Song, Shitao Fan, Gaoming Li, Wenzhe Sun, Zhixian Ye, Jiacheng Huang, Dahong Yang, Jinfu Ma, Xu Xu, Zhixi Wang, Lilan Wang, Guojian Liu, Fengli Li, Changwei Guo, Li Qi, Wenjie Zi   +22 more
wiley   +1 more source

‘Forging a conviction’ – participants’ experiences of a western acupuncture randomised controlled trial

, 2009
Research into acupuncture has shown that individuals continue to reportfavourable clinical effects despite the lack of systematic evidence supporting apoint specific therapeutic effect for real acupuncture treatment.
Hill, Clare Marie
core