Results 121 to 130 of about 11,169,970 (365)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Psychological Pressure in Competitive Environments: Evidence from a Randomized Natural Experiment: Comment [PDF]

Apesteguia and Palacios-Huerta (forthcoming) report for a sample of 129 shootouts from various seasons in ten different competitions that teams kicking first in soccer penalty shootouts win significantly more often than teams kicking second.
Kocher, Martin G., Lenz, Marc V., Sutter, Matthias   +2 more
core   +3 more sources

E‐cigarette support for smoking cessation: Identifying the effectiveness of intervention components in an on‐line randomized optimization experiment [PDF]

, 2023
Catherine Kimber, Vassilis Sideropoulos, Sharon Cox, Daniel Frings, Felix Naughton, Jamie Brown, Hayden McRobbie, Lynne Dawkins   +7 more
openalex   +1 more source

Family Networks and School Enrolment: Evidence from a Randomized Social Experiment [PDF]

We present evidence on whether and how a household's behavior is influenced by the presence and characteristics of its extended family. Using data from the PROGRESA program in Mexico, we exploit information on the paternal and maternal surnames of heads ...
Angelucci, Manuela, De Giorgi, Giacomo, Rangel, Marcos A., Rasul, Imran   +3 more
core  

Randomized experiments as the bronze standard [PDF]

Journal of Experimental Criminology, 2005
In this paper, the strengths and weakness of randomized field experiments are discussed. Although it seems to be common knowledge that random assignment balances experimental and control groups on all confounders, other features of randomized field experiments are somewhat less appreciated.
openaire   +4 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Replication Data for: Statistical Inference and Power Analysis for Direct and Spillover Effects in Two-Stage Randomized Experiments

, 2022
Zhichao Jiang, Kosuke Imai, Anup Malani
openalex   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

What Kind of EU Fiscal Capacity? Evidence From a Randomized Survey Experiment in Five European Countries in Times of Corona

, 2020
Roel M. W. J. Beetsma, Brian Burgoon, Francesco Nicoli, Anniek de Ruijter, Frank Vandenbroucke   +4 more
openalex   +1 more source

Illustrating Randomness in Statistics Courses with Spatial Experiments

, 2021
Amanda S. Hering, Luke Durell, Grant B. Morgan   +2 more
openalex   +1 more source