Results 41 to 50 of about 11,169,970 (365)

Detecting treatment interference under K-nearest-neighbors interference

Journal of Causal Inference
We propose a model of treatment interference where the response of a unit depends only on its treatment status and the statuses of units within its K-neighborhood.
Alzubaidi Samirah H., Higgins Michael J.
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Reframing cigarettes as social currency: A randomized survey experiment on the role of warning images and pricing

Tobacco Induced Diseases
Introduction In China, cigarettes function as both consumer goods and ‘social currency’. Despite increased awareness of smoking risks, cigarette gifting persists.
Yabin Xing, Wei Wen, Gang Wang, Kecheng Du   +3 more
doaj   +1 more source

Randomised Controlled Trial of an Online Version of Compassion Mind Training in a Nonclinical Sample

Europe's Journal of Psychology, 2020
Compassion Mind Training (CMT) is a therapeutic approach to guide highly self-critical individuals to generate compassion. The goal was to probe the efficacy of a short-term, online version of the CMT on self-compassion and self-criticism in a non ...
Júlia Halamová, Martin Kanovský, Alexandra Pačutová, Nuriye Kupeli   +3 more
doaj   +1 more source

Finding Alternatives to the Dogma of Power Based Sample Size Calculation: Is a Fixed Sample Size Prospective Meta-Experiment a Potential Alternative? [PDF]

PLoS ONE, 2016
Sample sizes for randomized controlled trials are typically based on power calculations. They require us to specify values for parameters such as the treatment effect, which is often difficult because we lack sufficient prior information.
Elsa Tavernier, Ludovic Trinquart, Bruno Giraudeau   +2 more
doaj   +1 more source

Rational planning and politicians' attitudes to spending and reform: replication and extension of a survey experiment [PDF]

, 2016
The rational planning cycle of formulating strategic goals and using performance information to assess implementation is assumed to assist decision-making by politicians. Empirical evidence for this assumption is, however, scarce.
Baekgaard, Martin, Desmidt, Sebastian, George, Bert, Nielsen, Poul   +3 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

MODE: Minimax Optimal Deterministic Experiments for Causal Inference in the Presence of Covariates

Entropy
Data-driven decision-making has become crucial across various domains. Randomization and re-randomization are standard techniques employed in controlled experiments to estimate causal effects in the presence of numerous pre-treatment covariates.
Shaohua Xu, Songnan Liu, Yongdao Zhou
doaj   +1 more source

Persuasive Messages for Improving Adherence to COVID-19 Prevention Behaviors: Randomized Online Experiment

JMIR Human Factors, 2023
BackgroundAdherence to nonpharmaceutical interventions for COVID-19, including physical distancing, masking, staying home while sick, and avoiding crowded indoor spaces, remains critical for limiting the spread of COVID-19.
Mehdi Mourali, Jamie L Benham, Raynell Lang, Madison M Fullerton, Jean-Christophe Boucher, Kirsten Cornelson, Robert J Oxoby, Cora Constantinescu, Theresa Tang, Deborah A Marshall, Jia Hu   +10 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source