Results 161 to 170 of about 24,154 (203)

Learned Conformational Space and Pharmacophore Into Molecular Foundational Model

Advanced Science, EarlyView.
The Ouroboros model introduces two orthogonal modules within a unified framework that independently learn molecular representations and generate chemical structures. This design enables flexible optimization strategies for each module and faithful structure reconstruction without prompts or noise.
Lin Wang, Yifan Wu, Hao Luo, Minglong Liang, Yihang Zhou, Cheng Chen, Chris Liu, Jun Zhang, Yang Zhang   +8 more
wiley   +1 more source

Mele's Digital Zygote: Developer Responsibility for Neural Networks. [PDF]

Sci Eng Ethics
Søgaard A, Stamatiou F.
europepmc   +1 more source

Loss of SOCS1 in Donor T Cells Exacerbates Intestinal GVHD by Driving a Chemokine‐Dependent Pro‐Inflammatory Immune Microenvironment

Advanced Science, EarlyView.
T cell‐specific Socs1 knockout leads to inflammatory differentiation of CD8+ T cells, prompting the STAT1/2 complex to drive the activation of Ccl5, Ccr5, and Cxcr3, and promoting the skewing of monocytes toward a pro‐inflammatory M1 macrophage lineage.
Zhigui Wu, Bixia Wang, Xinya Jiang, Fangqing Zhang, Qianqian Huang, Xinyi Wu, Shuang Fan, Qi Zhang, Jingrui Zhou, Jianing Tang, Xiao‐Dong Mo, Yu Wang, Ying‐Jun Chang, Huidong Guo, Xiao‐Jun Huang   +14 more
wiley   +1 more source

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

Mathematical strategies for predicting resistant subpopulations from scRNAseq data of a PANC-1 3D tissue model: Insight into gemcitabine resistance and TGFB1-induced invasion and EMT. [PDF]

Comput Struct Biotechnol J
Caliskan A, Crouch SAW, Pereira JGN, Dandekar T, Dandekar G, Breitenbach T.   +5 more
europepmc   +1 more source

Exploring the impact of the adaptive disclosure technique on reducing the severity of post-traumatic stress disorder symptoms in veterans: a study protocol for a randomized controlled trial. [PDF]

Trials
Malekzadeh M, Afzali SMA, Dasdar S.
europepmc   +1 more source

Association of high γ' fibrinogen levels with adverse events in patients with COVID-19. [PDF]

Blood Vessel Thromb Hemost
Revollido Q, Buzzard L, Lee DX, Strnad M, McLoud S, Khan A, Messer WB, Farrell DH.   +7 more
europepmc   +1 more source

Multimodality medical image fusion using directional total variation based linear spectral clustering in NSCT domain. [PDF]

Sci Rep
Khan MZ, Diwakar M, Srivastava P, Singh P, Pandey NK, Albuhairy MM, Algaraady J.   +6 more
europepmc   +1 more source

Enhancing Security in Visible Light Communication: A Tabu-Search-Based Method for Transmitter Selection. [PDF]

Sensors (Basel)
Shi G, Cheng W, Gao X, Wei F, Zhang H, Wang Q.   +5 more
europepmc   +1 more source

Community reservoirs of malaria parasites and gametocytes in Arba Minch district, southern Rift Valley, Ethiopia: a cross-sectional study. [PDF]

Malar J
Zewde Z, Eligo N, Tesfaye Y, Lindtjørn B, Massebo F.   +4 more
europepmc   +1 more source