Results 51 to 60 of about 453,286 (286)

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa, Daisuke Honda, Seigo Akari, Tadao Akizawa   +3 more
wiley   +1 more source

Spontaneous Symmetry Breaking and Phase Coexistence in Two-Color Networks

, 2015
We have considered an equilibrium ensemble of large Erd\H{o}s-Renyi topological random networks with fixed vertex degree and two types of vertices, black and white, prepared randomly with the bond connection probability, $p$.
Avetisov, V., Gorsky, A., Nechaev, S., Valba, O.   +3 more
core   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Scheduling Scheme of Age of Information Optimization for WPCN with Stochastic Arrivals Based on Short Packet Communication [PDF]

Jisuanji gongcheng
In the design of scheduling schemes for optimizing information freshness in time-sensitive Internet of Things (IoT) systems, existing studies often assume that the communication link between the sensor and the information receiving terminal is perfectly ...
MA Xiaoping, JIA Xiangdong, XUE Kailai, NIU Xiayang, ZHANG Liang
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Statistical Assessment of Shapes and Magnetic Field Orientations in Molecular Clouds through Polarization Observations [PDF]

, 2009
We present a novel statistical analysis aimed at deriving the intrinsic shapes and magnetic field orientations of molecular clouds using dust emission and polarization observations by the Hertz polarimeter.
Ballesteros-Paredes, Basu, Bethell, Binney, Burkert, C. D. Dowell, Corana, Curran, Dotson, Dotson, Dowell, Draine, Fiege, Fiege, Fiege, Gammie, Girart, Glenn, Hartmann, Hildebrand, Hoang, J. E. Vaillancourt, Jones, Jones, K. Tassis, Kane, Kerton, L. Kirby, Lai, Lazarian, Lazarian, Mouschovias, Naghizadeh-Khouei, R. H. Hildebrand, Schleuning, Schleuning, Tassis, Vaillancourt, Vall��e   +38 more
core   +3 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Shallow Unorganized Neural Networks Using Smart Neuron Model for Visual Perception

IEEE Access, 2019
The recent success of Deep Neural Networks (DNNs) has revealed the significant capability of neural computing in many challenging applications. Although DNNs are derived from emulating biological neurons, there still exist doubts over whether or not DNNs
Richard Jiang, Danny Crookes
doaj   +1 more source

The effects of inclusion on academic achievement, socioemotional development and wellbeing of children with special educational needs

Campbell Systematic Reviews, 2022
Background Considering the rapid global movement towards inclusion for students with special educational needs (SEN), there is a surprising lack of pedagogical or didactic theories regarding the ways in which inclusive education may affect students with ...
Nina T. Dalgaard, Anja Bondebjerg, Bjørn C. A. Viinholt, Trine Filges   +3 more
doaj   +1 more source