Results 71 to 80 of about 453,286 (286)
A method to reduce imbalance for site-level randomized stepped wedge implementation trial designs
Implementation Science, 2019 Background Controlled implementation trials often randomize the intervention at the site level, enrolling relatively few sites (e.g., 6–20) compared to trials that randomize by subject.
Robert A. Lew +5 more
doaj +1 more source
Complete moment convergence of double-indexed randomly weighted sums of mixing sequences [PDF]
Journal of Inequalities and Applications, 2016 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Jian Han, Yu Xiang
openaire +2 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Chinese Medical Journal, 2018 Background: Hypothermic machine perfusion (HMP) is being used more often in cardiac death kidney transplantation; however, the significance of assessing organ quality and predicting delayed graft function (DGF) by HMP parameters is still controversial ...
Chen-Guang Ding +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Detection of trend changes in time series using Bayesian inference
, 2011 Change points in time series are perceived as isolated singularities where two regular trends of a given signal do not match. The detection of such transitions is of fundamental interest for the understanding of the system's internal dynamics.
A. Gelman +8 more
core +1 more source
A note on the asymptotics for the randomly stopped weighted sums
Nonlinear Analysis: Modelling and Control, 2018 Let {Xi , i ⩾ 1} be a sequence of identically distributed real-valued random variables with common distribution FX; let {θi , i ⩾ 1} be a sequence of identically distributed, nonnegative and nondegenerate at zero random variables; and let τ be a positive integer-valued counting random variable.
Yang Yang, Xi Xi Shi, Xing Fang Huang
openaire +4 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
An exponential reduction in training data sizes for machine learning derived entanglement witnesses
Machine Learning: Science and TechnologyWe propose a support vector machine (SVM) based approach for generating an entanglement witness that requires exponentially less training data than previously proposed methods. SVMs generate hyperplanes represented by a weighted sum of expectation values
Aiden R Rosebush +3 more
doaj +1 more source
, 2018 We analyze a new random algorithm for numerical integration of $d$-variate functions over $[0,1]^d$ from a weighted Sobolev space with dominating mixed smoothness $\alpha\ge 0$ and product weights $1\ge\gamma_1\ge\gamma_2\ge\cdots>0$, where the functions
Kritzer, Peter +3 more
core +2 more sources