ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Image-Based Classification of Concrete Carbonation Using YOLO Models. [PDF]
Aydın Y +4 more
europepmc +1 more source
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao +6 more
wiley +1 more source
Hyperchaotic fractional-order image encryption with Knight's tour scrambling for satellite imagery. [PDF]
Mamdouh E, Aboshousha A, Alexan W.
europepmc +1 more source
ABSTRACT Objective High‐resolution MRI enables detailed assessment of intracranial vessel wall pathology in moyamoya vasculopathy. We aimed to classify adult moyamoya vasculopathy etiologies using high‐resolution MRI and to examine subtype‐specific associations between high‐resolution MRI features and ischemic infarction.
Guangsong Han +8 more
wiley +1 more source
Robustness is important: Limitations of LLMs for predictions on tabular data. [PDF]
Liu H, Yang M, Adomavicius G.
europepmc +1 more source
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers +7 more
wiley +1 more source
Deep reinforcement learning-based reversible medical image encryption framework for secure IoMT environments. [PDF]
Mahalakshmi K, Nagarajan S.
europepmc +1 more source
A Multi-Strategy Enhanced Whale Optimization Algorithm for Long Short-Term Memory-Application to Short-Term Power Load Forecasting for Microgrid Buildings. [PDF]
Qu L, Teng Q, Mai H, Chen J.
europepmc +1 more source
Cluster minimal sufficient balance (CMSB): an efficient covariate balancing randomization method for cluster randomized trials. [PDF]
Cai J +9 more
europepmc +1 more source

