Results 71 to 80 of about 166,149,217 (275)

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source

Comparative effects of kinesiotaping with and without combined chain exercises on pain, range of motion, and quality of life in knee osteoarthritis: a randomized controlled trial

Khyber Medical University Journal
Objectives: To compare the effects of Kinesio Taping (KT) with and without Combined Chain Exercises (CCEs) on pain, range of motion (ROM), and quality of life in patients with knee osteoarthritis (OA).
Sobia Maqbool, Hina Gul, Janisar Zainab, Rida Mustafa   +3 more
doaj   +1 more source

Joint congruity and the congruous range of motion applied to displaced intra-articular calcaneal fractures

, 1996
Bibliography: p. 155-169.
openaire   +2 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

ROS‐Targeted Nanomotor Therapy in OA: Cartilage Protection and Pain Relief

Advanced Science, EarlyView.
ROS‐responsive NM@MET nanomotors utilize elevated ROS in osteoarthritic joints to promote deep penetration into cartilage and synovium and enable sustained metformin release. By scavenging ROS, regulating NRF2/KEAP1 signaling, protecting chondrocytes, suppressing synovial inflammation, and attenuating nociceptive signaling, NM@MET alleviates pain and ...
Meng Zheng, Changyu Liu, Qin Xia, Arndt F. Schilling, Jiawei Jiang, Renpeng Peng, Zixing Shu, Tian Ma, Danni Luo, Yaoyu Zhang, Yibo Fan, Xuyuan Zhang, Song Li, Kai Wang, Wentao Ke, Yuan Xiong, Yuanli Zhu, Fangzhi Mou, Jun Xiao, Hao Zhu   +19 more
wiley   +1 more source

Association of Range of Motion Deficit and Recurrence of Pain After Treatment of Adhesive Capsulitis

Pain and Therapy
Introduction We evaluated the factors influencing the duration of significant pain reduction after conservative management for adhesive capsulitis (AC). Methods Follow-up for 6–8 months was performed with 141 patients with AC who experienced significant ...
Jung Hwan Lee, Jun Ho Lee, Min Cheol Chang   +2 more
doaj   +1 more source

Comparison of early postoperative functional activity levels of patients undergoing unilateral and bilateral total knee arthroplasty

Acta Orthopaedica et Traumatologica Turcica, 2020
Objectives: We compared early postoperative functional activities of patients undergoing unilateral and bilateral total knee arthroplasty (TKA).\r\nMethods: A total of 241 patients underwent bilateral (n=130; 12 men, 118 women; mean age 67.5±7.6 years ...
Serkan Bakirhan, Bayram Unver, Vasfi Karatosun   +2 more
doaj   +1 more source

Nanozyme‐Reinforced miR‐197‐3p Delivery Resets Metabolic and Senescence Pathways to Rejuvenate Osteoarthritic Cartilage

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a progressive and disabling joint disease driven by oxidative stress, chondrocyte senescence and extracellular matrix (ECM) degradation, yet lacks effective disease‐modifying treatments. In this study, we identified miR‐197‐3p as a previously unrecognized, cartilage‐protective miRNA significantly downregulated in both ...
Xuejie Cai, Zehui Lv, Chen Zhang, Xingdong Yang, Ruoying Wang, Yixin Bian, Jiawei Xu, Han Wang, Yingjie Wang, Long Bai, Jiacan Su, Xisheng Weng   +11 more
wiley   +1 more source

Changes in articular cartilage after meniscectomy and meniscus replacement using a biodegradable porous polymer implant [PDF]

, 2010
Purpose: To evaluate the long-term effects of implantation of a biodegradable polymer meniscus implant on articular cartilage degeneration and compare this to articular cartilage degeneration after meniscectomy.
Arend Jan Schouten, Buma, Pieter,, Schouten, Arend Jan,, Hannink, Gerjon, Buma, P., Buma, Pieter, Tienen, Tony G. van,, Tienen, T.G. van, Gerjon Hannink, Pieter Buma, Tienen, Tony G. van, Hannink, G.J., Schouten, A.J., Tony G. van Tienen, van Tienen, Tony G., Schouten, Arend Jan, de Mulder, E.L., Hannink, Gerjon,   +17 more
core   +6 more sources