Results 71 to 80 of about 2,449,997 (351)

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

Quantum Brownian Motion With Large Friction

, 2005
Quantum Brownian motion in the strong friction limit is studied based on the exact path integral formulation of dissipative systems. In this limit the time-nonlocal reduced dynamics can be cast into an effective equation of motion, the quantum ...
Averin D. V., Barone A., Feynman R. P., Grabert H., Hermann Grabert, Hänggi P., Ivanchenko Yu. M., Joachim Ankerhold, Jortner J., Korshunov S. E., Landau L. D., Philip Pechukas, Yang D. Y.   +12 more
core   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source

Effects and predictors of shoulder muscle massage for patients with posterior shoulder tightness

BMC Musculoskeletal Disorders, 2012
Background Clinical approaches like mobilization, stretching, and/or massage may decrease shoulder tightness and improve symptoms in subjects with stiff shoulders.
Yang Jing-lan, Chen Shiau-yee, Hsieh Ching-Lin, Lin Jiu-jenq   +3 more
doaj   +1 more source

What is the most appropriate method for the measurement of the range of motion in the lumbar spine and how does surgical fixation affect the range of movement of the lumbar spine in adolescent idiopathic scoliosis? A systematic review protocol

Systematic Reviews, 2022
Introduction Adolescent idiopathic scoliosis (AIS) is a three-dimensional rotational change in the normal shape of the spine which affects children aged 10 to 18 years.
Laura Hartley, Mattia Zappalà, Uzo Ehiogu, Nicola R. Heneghan, Adrian Gardner   +4 more
doaj   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Clinical and Radiographic Outcomes in Distal Radius Fractures Using K-wires versus Fragment-specific Plates: A Prospective Interventional Study

Journal of Clinical and Diagnostic Research
Introduction: Orthopaedic practice frequently deals with Distal Radius Fractures (DRFs); however, the treatment strategies for optimal functional outcomes remain uncertain.
Satyam Jawa, Vinod Nair
doaj   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Education and Simulation of Range of Motion (ROM) for Caregivers to Improve the Quality of Life of Older People in the Community

Ahmar Metakarya
The aging process has caused various health problems, including limited physical mobility due to muscle weakness, joint stiffness, and certain chronic disease conditions. Efforts to maintain the health of older people can be done through Range of Motion (
I Gede Putu Darma Suyasa, Ni Kadek Sutini, Israfil Israfil, Ni Luh Dwi Indrayani, Ni Luh Putu Inca Buntari Agustini, I Nyoman Trisna Oka Putra Oka Putra   +5 more
doaj   +1 more source

Complications of diabetes mellitus on muscles and joints of lower extremities [PDF]

Scripta Medica, 2018
Introduction: Non-enzymatic protein glycosylation in diabetic patients leads to stiffening of collagen-containing tissues affecting joint mobility. Motor dysfunction in diabetic patients can be detected as muscle weakness or atrophy.
Novaković-Bursać Snježana, Jandrić Slavica, Talić Goran, Ljubojević Gordana   +3 more
doaj