Results 71 to 80 of about 174,052,608 (250)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Foot function and normal coronal plane range-of-motion at the ankle-joint-complex [PDF]

, 2002
An investigation was carried out into normal coronal plane range-of-motion at the ankle-joint-complex. To facilitate this, an accurate and reliable measurement rig was designed.
Holland, M. David
core  

Investigation of tri-planar range of motion of ankle according to gender using photogrammetry technique

, 2020
The risk of ankle sprain during activities is very high. Therefore, studying ankle range of motion is important in order prevent any injuries. Photogrammetry is used to investigate tri-planar range of motion of ankle.
Al-Kharaz, Ali, Ali Al-Kharaz, Albert Chong, Chong, Albert   +3 more
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Education and Simulation of Range of Motion (ROM) for Caregivers to Improve the Quality of Life of Older People in the Community

Ahmar Metakarya
The aging process has caused various health problems, including limited physical mobility due to muscle weakness, joint stiffness, and certain chronic disease conditions. Efforts to maintain the health of older people can be done through Range of Motion (
I Gede Putu Darma Suyasa, Ni Kadek Sutini, Israfil Israfil, Ni Luh Dwi Indrayani, Ni Luh Putu Inca Buntari Agustini, I Nyoman Trisna Oka Putra Oka Putra   +5 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

The Timing of Feedback to Early Visual Cortex in the Perception of Long-Range Apparent Motion [PDF]

, 2008
When 2 visual stimuli are presented one after another in different locations, they are often perceived as one, but moving object. Feedback from area human motion complex hMT/V5+ to V1 has been hypothesized to play an important role in this illusory ...
Bledowski, C., Wolf Singer, Muckli, Lars, Kohler, A., Wibral, M., Wibral, Michael, Michael Wibral, Lars Muckli, Muckli, L., Bledowski, Christoph, Kohler, Axel, Singer, Wolf, Axel Kohler, Christoph Bledowski, Singer, W.   +14 more
core   +1 more source

Clinical and Radiographic Outcomes in Distal Radius Fractures Using K-wires versus Fragment-specific Plates: A Prospective Interventional Study

Journal of Clinical and Diagnostic Research
Introduction: Orthopaedic practice frequently deals with Distal Radius Fractures (DRFs); however, the treatment strategies for optimal functional outcomes remain uncertain.
Satyam Jawa, Vinod Nair
doaj   +1 more source