Results 251 to 260 of about 2,160,574 (295)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

The use of an integrated framework combining eco-evolutionary data and species distribution models to predict range shifts of species under changing climates. [PDF]

MethodsX
Lu WX, Rao GY.
europepmc   +1 more source

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Illuminating geographical patterns in species' range shifts

Global Change Biology, 2014
AbstractSpecies' range shifts in response to ongoing climate change have been widely documented, but although complex spatial patterns in species' responses are expected to be common, comprehensive comparisons of species' ranges over time have undergone little investigation.
Gaël Grenouillet, Lise Comte
exaly   +3 more sources

Can internal range structure predict range shifts?

Journal of Animal Ecology
Abstract Poleward and uphill range shifts are a common—but variable—response to climate change. We lack understanding regarding this interspecific variation; for example, functional traits show weak or mixed ability to predict range shifts. Characteristics of species' ranges may enhance prediction of range shifts.
Neil A Gilbert, Harold N Eyster
exaly   +3 more sources

Climate change and elevational range shifts in insects

Current Opinion in Insect Science, 2021
On mountains, unique in their steep and rapid climatic gradients, many insects are shifting their elevational range limits to track recent temperature change. In a review of the range shift literature to date, most of the 1478 montane insect populations tested so far are shifting to higher elevations, but there is conspicuous variation in the responses.
Christy M McCain, Chloe F Garfinkel
openaire   +2 more sources

Mating system shifts a species’ range

Evolution, 2019
Understanding the ecological and evolutionary mechanisms that shape a species' range is an important goal in evolutionary biology. Evidence indicates that mating system is an effective predictor of the global range of native species or naturalized alien plants, but the mechanisms underlying this predictability are not elaborated.
Xin‐Sheng Hu, Xin‐Xin Zhang, Wei Zhou, Ying Hu, Xi Wang, Xiao‐Yang Chen   +5 more
openaire   +2 more sources

Chemical-shift ranges in proteins

Journal of Magnetic Resonance (1969), 1992
The results of ab initio derivative Hartree-Fock calculations of the dipole and quadrupole shielding polarizabilities and hyperpolarizabilities of a number of small molecules are reported, together with estimates of the electric fields and field gradients present in proteins.
Joseph Augspurger, John G Pearson, Eric Oldfield, Clifford E Dykstra, Ki Deok Park, Dwight Schwartz   +5 more
openaire   +1 more source

Life‐history evolution in range‐shifting populations

Ecology, 2010
Most evolutionary theory does not deal with populations expanding or contracting in space. Invasive species, climate change, epidemics, and the breakdown of dispersal barriers, however, all create populations in this kind of spatial disequilibrium. Importantly, spatial disequilibrium can have important ecological and evolutionary outcomes.
Benjamin L, Phillips, Gregory P, Brown, Richard, Shine   +2 more
openaire   +2 more sources