Results 111 to 120 of about 3,522,972 (323)
FEBS Letters, EarlyView.This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao +7 more
wiley +1 more source
Single‐cell insights into the role of T cells in B‐cell malignancies
FEBS Letters, EarlyView.Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley +1 more source
Open-source artefact management [PDF]
, 2002 This paper presents the GENESIS project, which aims to develop an open-source, light-weight, process-aware (and process-neutral) workflow management system. In particukar OSCAR, the artefact repository, is discussed.
Boldyreff, Cornelia +2 more
core
Molecular Oncology, EarlyView.The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens +8 more
wiley +1 more source
Real rank versus nonnegative rank
Linear Algebra and its Applications, 2009 AbstractWe consider the set of m×n nonnegative real matrices and define the nonnegative rank of a matrix A to be the minimum k such that A=BC where B is m×k and C is k×n. Given that the real rank of A is j for some j, we give bounds on the nonnegative rank of A and A2.
Thomas J. Laffey, LeRoy B. Beasley
openaire +2 more sources
Molecular Oncology, EarlyView.Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever +1 more
wiley +1 more source
Preferences for rank in competition: Is first-place seeking stronger than last-place aversion? [PDF]
Judgment and Decision Making, 2020 The use of gamification to motivate engagement has greatly increased the number of ways in which people compete. Many of these competitions allow individuals to see how they rank as a competition progresses.
Steven M. Shechter, David J. Hardisty
doaj
Molecular Oncology, EarlyView.Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink +6 more
wiley +1 more source
Rank Correlation and Tests of Significance Involving No Assumption of Normality [PDF]
, 1936 Harold Hotelling +1 more
openalex +1 more source
Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells
Molecular Oncology, EarlyView.In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi +3 more
wiley +1 more source