Results 141 to 150 of about 3,778,288 (330)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Linear Transducers Simplify Roll Grinding
Measurement + Control, 1974 B. S. Pearn
doaj +1 more source
High-Dimensional Uncertainty Quantification via Rank- and Sample-Adaptive Tensor Regression.
, 2021 Zichang He, Zheng Zhang
openalex +1 more source
Reduced rank multinomial logistic regression in Markov chains with application to cognitive data
, 2021 Pei Wang +6 more
openalex +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Algebraic Methods for Structured Low-Rank Approximation. [PDF]
, 2013 Giorgio Ottaviani +2 more
openalex
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Pass-Efficient Randomized LU Algorithms for Computing Low-Rank Matrix Approximation [PDF]
, 2020 Bolong Zhang, Michael Mascagni
openalex +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source