Results 71 to 80 of about 3,522,972 (323)

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

open access: yesFEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa   +8 more
wiley   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

open access: yesFEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto   +2 more
wiley   +1 more source

Combining Threshold, Thurstonian and Classical Linear Models in Horse Genetic Evaluations for Endurance Competitions

open access: yesAnimals, 2020
The racing time and rank at finish traits are commonly used for endurance horse breeding programs as a measure of their performance. Even so, given the nature of endurance competitions, many horses do not finish the race.
Isabel Cervantes   +3 more
doaj   +1 more source

Ranking by rating [PDF]

open access: yesTheoretical Economics, 2018
Each item in a given collection is characterized by a set of possible performances. A (ranking) method is a function that assigns an ordering of the items to every performance profile. Ranking by Rating consists in evaluating each item's performance by using an exogenous rating function, and ranking items according to their performance ratings.
openaire   +4 more sources

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

A note on the rank inequality for diagonally magic matrices

open access: yesJournal of Inequalities and Applications, 2016
We prove that a positive matrix with all permutation products equal is diagonally equivalent to J, the all-1s matrix. Then we give a simple proof of the rank inequality for diagonally magic matrices (J. Inequal. Appl. 2015:318, 2015).
Duanmei Zhou, Qingyou Cai, Xiaoyan Chen
doaj   +1 more source

Active artefact management for distributed software engineering [PDF]

open access: yes, 2002
We describe a software artefact repository that provides its contents with some awareness of their own creation. "Active" artefacts are distinguished from their passive counterparts by their enriched meta-data model which reflects the work-flow process ...
Boldyreff, Cornelia   +2 more
core  

Social context prevents heat hormetic effects against mutagens during fish development

open access: yesFEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere   +5 more
wiley   +1 more source

Supporting collaboration within the eScience community [PDF]

open access: yes, 2004
Collaboration is a core activity at the heart of large-scale co- operative scientific experimentation. In order to support the emergence of Grid-based scientific collaboration, new models of e-Science working methods are needed.
Boldyreff, Cornelia   +2 more
core  

Ranking structures and rank–rank correlations of countries: The FIFA and UEFA cases [PDF]

open access: yesInternational Journal of Modern Physics C, 2014
Ranking of agents competing with each other in complex systems may lead to paradoxes according to the pre-chosen different measures. A discussion is presented on such rank–rank, similar or not, correlations based on the case of European countries ranked by UEFA and FIFA from different soccer competitions.
Ausloos, Marcel   +3 more
openaire   +3 more sources

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