Results 71 to 80 of about 3,725,370 (324)

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

open access: yesFEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer   +7 more
wiley   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

open access: yesFEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur   +5 more
wiley   +1 more source

Evaluation of Critical Thinking Skills in Isfahan University of Medical Sciences\' Students and Its Relationship with Their Rank in University Entrance Exam Rank [PDF]

open access: yesمجله ایرانی آموزش در علوم پزشکی, 2009
Introduction: Are the education students receive prior to entering the university, based on critical thinking skills? Are their scientific abilities associated with this thinking style? This study was designed with the aim of evaluating critical thinking
Zeynabossadat Athari   +3 more
doaj  

Regulation of neurite growth by tumour necrosis superfamily member RANKL [PDF]

open access: yesOpen Biology, 2013
RANKL (receptor-activator of NF-κB ligand, TNFSF11) is a member of the TNF superfamily that regulates bone remodelling and the development of the thymus, lymph nodes and mammary glands.
Humberto Gutierrez   +5 more
doaj   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Instituer la toute-puissance ? Les rapports d’autorité dans la France d’Ancien Régime

open access: yesTracés, 2009
This paper proposes to explore power mechanisms in the early modern French monarchy, through the relations induced by the disputes for precedence. Tensions were manifold between subjects who considered ranks as inheritances and were intent on preserving ...
Fanny Cosandey
doaj   +1 more source

Astronomical application of IR CID technology [PDF]

open access: yes
A portable microcomputer data system was developed to test a 2 x 64-element Si:Bi charge injection device (CID) infrared detector array on the Lick Observatory Shane telescope. An existing 0.5 m spectrograph was used for the tests after modification, and
Rank, D. M.
core   +1 more source

COMPARATIVE ANALYSIS OF WEBOMETRICS RANKING STATE AND PRIVATE UNIVERSITY IN INDONESIA RANKING WITH PROMETHEE AND VIKOR METHODS [PDF]

open access: yes, 2012
The research was conducted to determine the comparative rank among academics website rank in Indonesia by using the promethee and vikor method with Webometrics rank. This study used two instruments, google search engine and web crawler socscibot.
Anandita, Bagus Wicaksono
core  

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

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