Results 111 to 120 of about 496,714 (284)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Librarian, Heal Thyself: A Scholarly Communication Analysis of LIS Journals
In Brief This article presents an analysis of 111 Library and Information Science journals based on measurements of “openness” including copyright policies, open access self-archiving policies and open access publishing options.
Micah Vandegrift
doaj
Massive spin 3 and Metric-Affine Gravity
Symmetric Metric-Affine Gravity is a theory of gravity with an independent non-metric connection, and zero torsion. It can be thought of as ordinary metric gravity coupled to a rank-3 tensor Q, symmetric in one pair of indices.
Roberto Percacci, Ergin Sezgin
doaj +1 more source
Decoding Rank Metric Reed–Muller Codes
In this article, we investigate the decoding of the rank metric Reed--Muller codes introduced by Augot, Couvreur, Lavauzelle and Neri in 2021. These codes are defined from Abelian Galois extensions extending the construction of Gabidulin codes over arbitrary cyclic Galois extensions. We propose a polynomial time algorithm that rests on the structure of
Alain Couvreur, Rakhi Pratihar
openaire +2 more sources
Time after time – circadian clocks through the lens of oscillator theory
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Ricci-flat metrics and Killing-Yano tensors
We consider the problem of constructing Ricci-flat metrics on the total space of the canonical bundle over the del Pezzo surface of rank one. We analyze the so-called ‘orthotoric metric’ and its first-order deformation, whose existence is compatible with
Bykov Dmitri
doaj +1 more source
Higher dominance rank is associated with lower glucocorticoids in wild female baboons: A rank metric comparison. [PDF]
Levy EJ +11 more
europepmc +1 more source

